Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346028609> ?p ?o ?g. }
- W2346028609 abstract "Abstract Photodynamic therapy (PDT) with protoporphyrin IX (PpIX), which is endogenously derived from 5-aminolevulinic acid (5-ALA) or its derivatives, is a promising modality for the treatment of both pre-malignant and malignant lesions. However, the mechanisms of how ALA-induced PpIX selectively accumulated in the tumors are not fully elucidated. Here we discovered that eukaryotic translation elongation factor 1 alpha 1 (eEF1A1) interacted with PpIX (with an affinity constant of 2.96 × 10 6 M −1 ). Microscopy imaging showed that ALA-induced PpIX was co-localized with eEF1A1 in cancer cells. eEF1A1 was found to enrich ALA-induced PpIX in cells by competitively blocking the downstream bioavailability of PpIX. Taken together, our study discovered eEF1A1 as a novel photosensitizer binding protein, which may play an essential role in the enrichment of ALA-induced PpIX in cancer cells during PDT. These suggested eEF1A1 as a molecular marker to predict the selectivity and efficiency of 5-ALA based PDT in cancer therapy." @default.
- W2346028609 created "2016-06-24" @default.
- W2346028609 creator A5000356911 @default.
- W2346028609 creator A5010628708 @default.
- W2346028609 creator A5017209334 @default.
- W2346028609 creator A5029963577 @default.
- W2346028609 creator A5049592599 @default.
- W2346028609 creator A5070448032 @default.
- W2346028609 creator A5071037763 @default.
- W2346028609 creator A5074745823 @default.
- W2346028609 creator A5078707967 @default.
- W2346028609 date "2016-05-06" @default.
- W2346028609 modified "2023-10-18" @default.
- W2346028609 title "eEF1A1 binds and enriches protoporphyrin IX in cancer cells in 5-aminolevulinic acid based photodynamic therapy" @default.
- W2346028609 cites W1560901632 @default.
- W2346028609 cites W162750623 @default.
- W2346028609 cites W1658511910 @default.
- W2346028609 cites W1664724705 @default.
- W2346028609 cites W1841423094 @default.
- W2346028609 cites W1966167142 @default.
- W2346028609 cites W1980313235 @default.
- W2346028609 cites W1981981290 @default.
- W2346028609 cites W1985006984 @default.
- W2346028609 cites W1988590162 @default.
- W2346028609 cites W1990324858 @default.
- W2346028609 cites W1995316524 @default.
- W2346028609 cites W1997228748 @default.
- W2346028609 cites W1999142777 @default.
- W2346028609 cites W2011874398 @default.
- W2346028609 cites W2018321060 @default.
- W2346028609 cites W2022050193 @default.
- W2346028609 cites W2025845392 @default.
- W2346028609 cites W2026046421 @default.
- W2346028609 cites W2031213514 @default.
- W2346028609 cites W2034465320 @default.
- W2346028609 cites W2035650745 @default.
- W2346028609 cites W2036205949 @default.
- W2346028609 cites W2038630817 @default.
- W2346028609 cites W2049726001 @default.
- W2346028609 cites W2067442819 @default.
- W2346028609 cites W2075017779 @default.
- W2346028609 cites W2076865122 @default.
- W2346028609 cites W2080415474 @default.
- W2346028609 cites W2083928750 @default.
- W2346028609 cites W2087328712 @default.
- W2346028609 cites W2087662771 @default.
- W2346028609 cites W2091906758 @default.
- W2346028609 cites W2092321388 @default.
- W2346028609 cites W2092577444 @default.
- W2346028609 cites W2093590577 @default.
- W2346028609 cites W2098091457 @default.
- W2346028609 cites W2110005706 @default.
- W2346028609 cites W2113478861 @default.
- W2346028609 cites W2133576799 @default.
- W2346028609 cites W2139569318 @default.
- W2346028609 cites W2140944160 @default.
- W2346028609 cites W2149060516 @default.
- W2346028609 cites W2157126494 @default.
- W2346028609 cites W2163443807 @default.
- W2346028609 cites W2167279371 @default.
- W2346028609 cites W2168528571 @default.
- W2346028609 cites W2273130575 @default.
- W2346028609 cites W2415103746 @default.
- W2346028609 cites W984181354 @default.
- W2346028609 doi "https://doi.org/10.1038/srep25353" @default.
- W2346028609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4858656" @default.
- W2346028609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27150264" @default.
- W2346028609 hasPublicationYear "2016" @default.
- W2346028609 type Work @default.
- W2346028609 sameAs 2346028609 @default.
- W2346028609 citedByCount "10" @default.
- W2346028609 countsByYear W23460286092017 @default.
- W2346028609 countsByYear W23460286092018 @default.
- W2346028609 countsByYear W23460286092020 @default.
- W2346028609 countsByYear W23460286092021 @default.
- W2346028609 countsByYear W23460286092023 @default.
- W2346028609 crossrefType "journal-article" @default.
- W2346028609 hasAuthorship W2346028609A5000356911 @default.
- W2346028609 hasAuthorship W2346028609A5010628708 @default.
- W2346028609 hasAuthorship W2346028609A5017209334 @default.
- W2346028609 hasAuthorship W2346028609A5029963577 @default.
- W2346028609 hasAuthorship W2346028609A5049592599 @default.
- W2346028609 hasAuthorship W2346028609A5070448032 @default.
- W2346028609 hasAuthorship W2346028609A5071037763 @default.
- W2346028609 hasAuthorship W2346028609A5074745823 @default.
- W2346028609 hasAuthorship W2346028609A5078707967 @default.
- W2346028609 hasBestOaLocation W23460286091 @default.
- W2346028609 hasConcept C104317684 @default.
- W2346028609 hasConcept C121608353 @default.
- W2346028609 hasConcept C12554922 @default.
- W2346028609 hasConcept C126322002 @default.
- W2346028609 hasConcept C178790620 @default.
- W2346028609 hasConcept C185592680 @default.
- W2346028609 hasConcept C2779671804 @default.
- W2346028609 hasConcept C2781323092 @default.
- W2346028609 hasConcept C2781469039 @default.
- W2346028609 hasConcept C502942594 @default.
- W2346028609 hasConcept C55493867 @default.
- W2346028609 hasConcept C67705224 @default.
- W2346028609 hasConcept C71924100 @default.