FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346068051> ?p ?o ?g. }

• W2346068051 abstract "Mycotoxins are secondary metabolites produced by fungal species which can usually be found in foodstuffs. Regulation (EC) 1881/2006, partially amended by other Regulations, sets maximum contents of some mycotoxins in different foodstuffs allowing to evaluate risks and take actions to protect public health. Contaminated crops such as cereals and cereal-based products are the main source of mycotoxins and they represent one of the most consumed commodity. Therefore, in this PhD Thesis rapid and selective analytical procedures based on gas chromatography tandem mass spectrometry (GC-MS/MS), with triple quadrupole mass analyzer (QqQ), were developed in order to determine Fusarium mycotoxins in several food matrices, mainly in those widely consumed. Proposed methodologies were validated according to the European guidelines recommendations and satisfactory results were obtained. Occurrence of mycotoxins was found in an important percentage of samples. Wheat-based products showed the highest incidence of mycotoxins (67.6%); nonetheless, the mycotoxin levels found were lower than the maximum permitted contents. Co-occurrence of mycotoxins was also found in 10.8% of analyzed food matrices (n = 418), being deoxynivalenol and HT-2 toxin the most frequent combination found. An exposure assessment was carried out by combining food consumption data and the results of mycotoxin contamination here obtained. In general terms, mycotoxin daily intakes were lower than tolerable daily intakes and thus, the exposure to these food contaminants would not imply a risk for the average consumer. However, special attention should be paid to susceptible population groups such as children since they show a higher exposure due to their wide cereal consumption and their lower body weight. On the other hand, an analytical method for determining mycotoxins and metabolites in human urine was developed and validated. Moreover, an enzymatic hydrolysis by β-glucuronidase was applied to liberate mycotoxins from Phase II metabolism products. The cleavage of DON glucuronide by β-glucuronidase hydrolysis allowed the total DON quantitation. Results showed occurrence of mycotoxins in 69% of analyzed samples (n = 55) being deoxynivalenol the most frequent toxin. Conjugation rate here experimentally obtained was greater than 70%. The exposure to mycotoxins was also assessed throughout the obtained concentration from the analyzed urine samples. It was obtained a deoxynivalenol intake above 50% of the provisional tolerable daily intake in over 50% of the individuals. One tenth of exposed subjects exceeded the safety levels. So, exposure data obtained by urine analysis were higher than those calculated by food analysis. Finally, taken into account the correlation between intake and excretion of mycotoxins, and in order to reduce the uncertainty associated to the assessment through the analysis of food, mycotoxin biomarkers in urine are suggested to carry out exposure studies." @default.
• W2346068051 created "2016-06-24" @default.
• W2346068051 creator A5017309590 @default.
• W2346068051 date "2015-01-01" @default.
• W2346068051 modified "2023-09-27" @default.
• W2346068051 title "Analytical study and exposure to Fusarium mycotoxins = Estudio analítico y de exposición a micotoxinas de Fusarium" @default.
• W2346068051 hasPublicationYear "2015" @default.
• W2346068051 type Work @default.
• W2346068051 sameAs 2346068051 @default.
• W2346068051 citedByCount "0" @default.
• W2346068051 crossrefType "journal-article" @default.
• W2346068051 hasAuthorship W2346068051A5017309590 @default.
• W2346068051 hasConcept C112570922 @default.
• W2346068051 hasConcept C185592680 @default.
• W2346068051 hasConcept C18903297 @default.
• W2346068051 hasConcept C2777140777 @default.
• W2346068051 hasConcept C2778431908 @default.
• W2346068051 hasConcept C2778867309 @default.
• W2346068051 hasConcept C2908647359 @default.
• W2346068051 hasConcept C31903555 @default.
• W2346068051 hasConcept C33070731 @default.
• W2346068051 hasConcept C59822182 @default.
• W2346068051 hasConcept C71924100 @default.
• W2346068051 hasConcept C84699730 @default.
• W2346068051 hasConcept C86803240 @default.
• W2346068051 hasConcept C99454951 @default.
• W2346068051 hasConceptScore W2346068051C112570922 @default.
• W2346068051 hasConceptScore W2346068051C185592680 @default.
• W2346068051 hasConceptScore W2346068051C18903297 @default.
• W2346068051 hasConceptScore W2346068051C2777140777 @default.
• W2346068051 hasConceptScore W2346068051C2778431908 @default.
• W2346068051 hasConceptScore W2346068051C2778867309 @default.
• W2346068051 hasConceptScore W2346068051C2908647359 @default.
• W2346068051 hasConceptScore W2346068051C31903555 @default.
• W2346068051 hasConceptScore W2346068051C33070731 @default.
• W2346068051 hasConceptScore W2346068051C59822182 @default.
• W2346068051 hasConceptScore W2346068051C71924100 @default.
• W2346068051 hasConceptScore W2346068051C84699730 @default.
• W2346068051 hasConceptScore W2346068051C86803240 @default.
• W2346068051 hasConceptScore W2346068051C99454951 @default.
• W2346068051 hasLocation W23460680511 @default.
• W2346068051 hasOpenAccess W2346068051 @default.
• W2346068051 hasPrimaryLocation W23460680511 @default.
• W2346068051 hasRelatedWork W1519806937 @default.
• W2346068051 hasRelatedWork W2039453015 @default.
• W2346068051 hasRelatedWork W2046142161 @default.
• W2346068051 hasRelatedWork W2068578276 @default.
• W2346068051 hasRelatedWork W2288154512 @default.
• W2346068051 hasRelatedWork W2299120494 @default.
• W2346068051 hasRelatedWork W2501470739 @default.
• W2346068051 hasRelatedWork W2746281339 @default.
• W2346068051 hasRelatedWork W2790471545 @default.
• W2346068051 hasRelatedWork W2889349158 @default.
• W2346068051 hasRelatedWork W2892723437 @default.
• W2346068051 hasRelatedWork W2898511831 @default.
• W2346068051 hasRelatedWork W2955027608 @default.
• W2346068051 hasRelatedWork W3005664831 @default.
• W2346068051 hasRelatedWork W3097258312 @default.
• W2346068051 hasRelatedWork W3165436280 @default.
• W2346068051 hasRelatedWork W3169739890 @default.
• W2346068051 hasRelatedWork W3175012512 @default.
• W2346068051 hasRelatedWork W3188870213 @default.
• W2346068051 hasRelatedWork W3209362988 @default.
• W2346068051 isParatext "false" @default.
• W2346068051 isRetracted "false" @default.
• W2346068051 magId "2346068051" @default.
• W2346068051 workType "article" @default.