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- W2346075947 abstract "Selecting a number of beams and their orientations in intensity-modulated radiation therapy (IMRT) is an important, but large-scale NP-hard optimization problem. Unfortunately, the quality of beam directions depends heavily on its cor- responding beam intensity profiles. Usually, the number of beams is manually pre-determinedandpassedforastochasticselectorwhichoptimizesbeamorientations, and then a single objective inverse treatment planning algorithm is used for optimiz- ing beam intensity profiles. The overall time needed to solve the inverse planning for every random selection of beam orientations becomes excessive. Therefore selecting an appropriate set of beam directions in IMRT is still a time-consuming manual trial- and-errorsearchprocedurethatdependsonintuitionandempiricalknowledge.During thelastdecade considerableprogresshasbeenmadeinoptimizingbeamintensitypro- files by using multi-objective inverse treatment planning. Multi-criteria optimization results in a variety of beam intensity profiles for every selection of beam orienta- tions. The planner then needs to search, manually, through this variety of solutions to decide upon an optimal plan. This work takes advantage of this human interaction to present a two-phase algorithm in which both processes of beam orientations and multi-criteria optimization with human guidelines cooperate together to determine a suitable number of beams and their orientations in a clinically practical time-slot. To illustrate the efficiency of the algorithm it has been applied to one artificial example and three real clinical cases. The results show that using the algorithm, both target coverage and sparing critical structures were significantly improved compared to the standard equally spaced beam plans. Moreover in some cases the algorithm suggested" @default.
- W2346075947 created "2016-06-24" @default.
- W2346075947 creator A5061145294 @default.
- W2346075947 date "2016-01-01" @default.
- W2346075947 modified "2023-09-23" @default.
- W2346075947 title "Pseudo-automatic beam orientations in multi-criteria intensity-modulated radiation therapy" @default.
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