Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346122647> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2346122647 endingPage "48.33" @default.
- W2346122647 startingPage "48.33" @default.
- W2346122647 abstract "Abstract Tumor cells initiate angiogenesis within the tumor micro-environment. The maintenance of these newly formed vessels is highly dependent on the migration and recruitment of immune cells. In previous studies, we have demonstrated that chronic morphine administration suppresses tumor cell induced angiogenesis to inhibit tumor growth in mice. Here we tested the hypothesis that a known immunosuppressant as morphine also regulates immune cell recruitment into- and migration towards a tumor microenvironment. To mimic a tumor microenvironment, matrigel was admixed with conditioned media derived from Lewis lung carcinoma cells (LLCCM) and implanted subcutaneous in WT or Mu-Opioid Receptor knockout mice (MORKO) treated with saline or morphine through pellet implantation. Interestingly, plugs taken from placebo treated mice (day 7) showed significant leukocyte infiltration, greater than that compared to plugs from morphine treated mice (p<0.05) and this effect was abolished in MORKO mice. Similarly, morphine suppressed the recruitment of adoptively transferred luciferase expressing bone marrow derived cells (known to contribute to tumor growth) into PVA sponges-presoaked with LLCCM and implanted subcutaneous in mice- pretreated with placebo or morphine. Taken together, these studies suggest that morphine treatment can potentially decrease solid tumor associated inflammation to reduce angiogenesis associated with increased tumor growth." @default.
- W2346122647 created "2016-06-24" @default.
- W2346122647 creator A5004845102 @default.
- W2346122647 creator A5014632236 @default.
- W2346122647 creator A5040468162 @default.
- W2346122647 creator A5066906833 @default.
- W2346122647 creator A5077274375 @default.
- W2346122647 creator A5085548742 @default.
- W2346122647 date "2011-04-01" @default.
- W2346122647 modified "2023-10-18" @default.
- W2346122647 title "Morphine inhibits recruitment of tumor promoting leukocytes (48.33)" @default.
- W2346122647 doi "https://doi.org/10.4049/jimmunol.186.supp.48.33" @default.
- W2346122647 hasPublicationYear "2011" @default.
- W2346122647 type Work @default.
- W2346122647 sameAs 2346122647 @default.
- W2346122647 citedByCount "0" @default.
- W2346122647 crossrefType "journal-article" @default.
- W2346122647 hasAuthorship W2346122647A5004845102 @default.
- W2346122647 hasAuthorship W2346122647A5014632236 @default.
- W2346122647 hasAuthorship W2346122647A5040468162 @default.
- W2346122647 hasAuthorship W2346122647A5066906833 @default.
- W2346122647 hasAuthorship W2346122647A5077274375 @default.
- W2346122647 hasAuthorship W2346122647A5085548742 @default.
- W2346122647 hasConcept C121332964 @default.
- W2346122647 hasConcept C121608353 @default.
- W2346122647 hasConcept C126322002 @default.
- W2346122647 hasConcept C153400128 @default.
- W2346122647 hasConcept C170493617 @default.
- W2346122647 hasConcept C185592680 @default.
- W2346122647 hasConcept C203014093 @default.
- W2346122647 hasConcept C2776107976 @default.
- W2346122647 hasConcept C2776914184 @default.
- W2346122647 hasConcept C2777389121 @default.
- W2346122647 hasConcept C2777847059 @default.
- W2346122647 hasConcept C2778608917 @default.
- W2346122647 hasConcept C2779013556 @default.
- W2346122647 hasConcept C2780007613 @default.
- W2346122647 hasConcept C2780394083 @default.
- W2346122647 hasConcept C2781063702 @default.
- W2346122647 hasConcept C502942594 @default.
- W2346122647 hasConcept C71924100 @default.
- W2346122647 hasConcept C8891405 @default.
- W2346122647 hasConcept C97355855 @default.
- W2346122647 hasConcept C98274493 @default.
- W2346122647 hasConceptScore W2346122647C121332964 @default.
- W2346122647 hasConceptScore W2346122647C121608353 @default.
- W2346122647 hasConceptScore W2346122647C126322002 @default.
- W2346122647 hasConceptScore W2346122647C153400128 @default.
- W2346122647 hasConceptScore W2346122647C170493617 @default.
- W2346122647 hasConceptScore W2346122647C185592680 @default.
- W2346122647 hasConceptScore W2346122647C203014093 @default.
- W2346122647 hasConceptScore W2346122647C2776107976 @default.
- W2346122647 hasConceptScore W2346122647C2776914184 @default.
- W2346122647 hasConceptScore W2346122647C2777389121 @default.
- W2346122647 hasConceptScore W2346122647C2777847059 @default.
- W2346122647 hasConceptScore W2346122647C2778608917 @default.
- W2346122647 hasConceptScore W2346122647C2779013556 @default.
- W2346122647 hasConceptScore W2346122647C2780007613 @default.
- W2346122647 hasConceptScore W2346122647C2780394083 @default.
- W2346122647 hasConceptScore W2346122647C2781063702 @default.
- W2346122647 hasConceptScore W2346122647C502942594 @default.
- W2346122647 hasConceptScore W2346122647C71924100 @default.
- W2346122647 hasConceptScore W2346122647C8891405 @default.
- W2346122647 hasConceptScore W2346122647C97355855 @default.
- W2346122647 hasConceptScore W2346122647C98274493 @default.
- W2346122647 hasIssue "1_Supplement" @default.
- W2346122647 hasLocation W23461226471 @default.
- W2346122647 hasOpenAccess W2346122647 @default.
- W2346122647 hasPrimaryLocation W23461226471 @default.
- W2346122647 hasRelatedWork W1975707813 @default.
- W2346122647 hasRelatedWork W1993674406 @default.
- W2346122647 hasRelatedWork W1999400932 @default.
- W2346122647 hasRelatedWork W2013286654 @default.
- W2346122647 hasRelatedWork W2111569334 @default.
- W2346122647 hasRelatedWork W2382888825 @default.
- W2346122647 hasRelatedWork W2601478625 @default.
- W2346122647 hasRelatedWork W3098689426 @default.
- W2346122647 hasRelatedWork W4206871862 @default.
- W2346122647 hasRelatedWork W4287435042 @default.
- W2346122647 hasVolume "186" @default.
- W2346122647 isParatext "false" @default.
- W2346122647 isRetracted "false" @default.
- W2346122647 magId "2346122647" @default.
- W2346122647 workType "article" @default.