Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346133077> ?p ?o ?g. }
- W2346133077 endingPage "478" @default.
- W2346133077 startingPage "472" @default.
- W2346133077 abstract "Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable responses to targeted therapy are rare in individuals with advanced-stage solid cancers. Even the most effective targeted therapies generally do not induce a complete tumor response, resulting in residual disease and tumor progression that limits patient survival. We discuss the emerging need to more fully understand the molecular basis of residual disease as a prelude to designing therapeutic strategies to minimize or eliminate residual disease so that we can move from temporary to chronic control of disease, or a cure, for patients with advanced-stage solid cancers. Ultimately, we propose a shift from the current reactive paradigm of analyzing and treating acquired drug resistance to a pre-emptive paradigm of defining the mechanisms that result in residual disease, to target and limit this disease reservoir." @default.
- W2346133077 created "2016-06-24" @default.
- W2346133077 creator A5004509086 @default.
- W2346133077 creator A5034705456 @default.
- W2346133077 date "2016-05-01" @default.
- W2346133077 modified "2023-09-26" @default.
- W2346133077 title "A framework for understanding and targeting residual disease in oncogene-driven solid cancers" @default.
- W2346133077 cites W100143889 @default.
- W2346133077 cites W1244344381 @default.
- W2346133077 cites W1546552389 @default.
- W2346133077 cites W1753838146 @default.
- W2346133077 cites W1914351667 @default.
- W2346133077 cites W1943756471 @default.
- W2346133077 cites W1946441967 @default.
- W2346133077 cites W1969391810 @default.
- W2346133077 cites W1971947883 @default.
- W2346133077 cites W1974903221 @default.
- W2346133077 cites W1982333694 @default.
- W2346133077 cites W1983762572 @default.
- W2346133077 cites W1983774108 @default.
- W2346133077 cites W1985264867 @default.
- W2346133077 cites W1987191607 @default.
- W2346133077 cites W1991365287 @default.
- W2346133077 cites W1997870023 @default.
- W2346133077 cites W1999025555 @default.
- W2346133077 cites W2004295816 @default.
- W2346133077 cites W2005274657 @default.
- W2346133077 cites W2013138515 @default.
- W2346133077 cites W2014881369 @default.
- W2346133077 cites W2022540958 @default.
- W2346133077 cites W2029480581 @default.
- W2346133077 cites W2033708806 @default.
- W2346133077 cites W2041255253 @default.
- W2346133077 cites W2043058822 @default.
- W2346133077 cites W2043707675 @default.
- W2346133077 cites W2044246917 @default.
- W2346133077 cites W2049122064 @default.
- W2346133077 cites W2050146483 @default.
- W2346133077 cites W2051841073 @default.
- W2346133077 cites W2052005627 @default.
- W2346133077 cites W2055624262 @default.
- W2346133077 cites W2059586354 @default.
- W2346133077 cites W2060427373 @default.
- W2346133077 cites W2065293650 @default.
- W2346133077 cites W2076178766 @default.
- W2346133077 cites W2076865561 @default.
- W2346133077 cites W2079015343 @default.
- W2346133077 cites W2080534618 @default.
- W2346133077 cites W2092437923 @default.
- W2346133077 cites W2096156234 @default.
- W2346133077 cites W2096387850 @default.
- W2346133077 cites W2097080587 @default.
- W2346133077 cites W2102212449 @default.
- W2346133077 cites W2102365935 @default.
- W2346133077 cites W2103557568 @default.
- W2346133077 cites W2103980474 @default.
- W2346133077 cites W2106391833 @default.
- W2346133077 cites W2108371618 @default.
- W2346133077 cites W2109387929 @default.
- W2346133077 cites W2111490539 @default.
- W2346133077 cites W2123431502 @default.
- W2346133077 cites W2123798150 @default.
- W2346133077 cites W2125974203 @default.
- W2346133077 cites W2126177831 @default.
- W2346133077 cites W2130027352 @default.
- W2346133077 cites W2131040858 @default.
- W2346133077 cites W2133523341 @default.
- W2346133077 cites W2137228442 @default.
- W2346133077 cites W2140126391 @default.
- W2346133077 cites W2141386558 @default.
- W2346133077 cites W2142865455 @default.
- W2346133077 cites W2146737519 @default.
- W2346133077 cites W2151337547 @default.
- W2346133077 cites W2154149901 @default.
- W2346133077 cites W2156078931 @default.
- W2346133077 cites W2156560090 @default.
- W2346133077 cites W2157090777 @default.
- W2346133077 cites W2162901058 @default.
- W2346133077 cites W2165267644 @default.
- W2346133077 cites W2166662937 @default.
- W2346133077 cites W2171549753 @default.
- W2346133077 cites W2182315038 @default.
- W2346133077 cites W2205646851 @default.
- W2346133077 cites W2219581640 @default.
- W2346133077 cites W2272802268 @default.
- W2346133077 cites W2318674152 @default.
- W2346133077 cites W2342552267 @default.
- W2346133077 cites W237988019 @default.
- W2346133077 cites W2395159409 @default.
- W2346133077 cites W2430474042 @default.
- W2346133077 cites W2572174216 @default.
- W2346133077 cites W2067904749 @default.
- W2346133077 doi "https://doi.org/10.1038/nm.4091" @default.
- W2346133077 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5384713" @default.
- W2346133077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27149220" @default.
- W2346133077 hasPublicationYear "2016" @default.
- W2346133077 type Work @default.
- W2346133077 sameAs 2346133077 @default.