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- W2346162161 endingPage "1153" @default.
- W2346162161 startingPage "1145" @default.
- W2346162161 abstract "We hypothesized that metabolic adaptations to muscle inactivity are most pronounced when neurotrophic influence is disrupted. In rat diaphragm muscle (Dia(m)), 2 wk of unilateral denervation or tetrodotoxin nerve blockade resulted in a reduction in succinate dehydrogenase (SDH) activity of type I, IIa, and IIx fibers (approximately 50, 70, and 24%, respectively) and a decrease in SDH variability among fibers (approximately 63%). In contrast, inactivity induced by spinal cord hemisection at C2 (ST) resulted in much less change in SDH activity of type I and IIa fibers (approximately 27 and 24%, respectively) and only an approximately 30% reduction in SDH variability among fibers. Actomyosin adenosinetriphosphatase (ATPase) activities of type I, IIx, and IIb fibers in denervated and tetrodotoxin-treated Dia(m) were reduced by approximately 20, 45, and 60%, respectively, and actomyosin ATPase variability among fibers was approximately 60% lower. In contrast, only actomyosin ATPase activity of type IIb fibers was reduced (approximately 20%) in ST Dia(m). These results suggest that disruption of neurotrophic influence has a greater impact on muscle fiber metabolic properties than inactivity per se." @default.
- W2346162161 created "2016-06-24" @default.
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- W2346162161 date "1997-04-01" @default.
- W2346162161 modified "2023-10-17" @default.
- W2346162161 title "Metabolic and phenotypic adaptations of diaphragm muscle fibers with inactivation" @default.
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- W2346162161 doi "https://doi.org/10.1152/jappl.1997.82.4.1145" @default.
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