FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346184067> ?p ?o ?g. }

• W2346184067 endingPage "44" @default.
• W2346184067 startingPage "23" @default.
• W2346184067 abstract "Microglia/macrophages are the major immune cells involved in the defence against brain damage. Their morphology and functional changes are correlated with the release of danger signals induced by stroke. These cells are normally responsible for clearing away dead neural cells and restoring neuronal functions. However, when excessively activated by the damage-associated molecular patterns following stroke, they can produce a large number of proinflammatory cytokines that can disrupt neural cells and the blood-brain barrier and influence neurogenesis. These effects indicate the important roles of microglia/macrophages in the pathophysiological processes of stroke. However, the modifiable and adaptable nature of microglia/macrophages may also be beneficial for brain repair and not just result in damage. These distinct roles may be attributed to the different microglia/macrophage phenotypes because the M1 population is mainly destructive, while the M2 population is neuroprotective. Additionally, different gene expression signature changes in microglia/macrophages have been found in diverse inflammatory milieus. These biofunctional features enable dual roles for microglia/macrophages in brain damage and repair. Currently, it is thought that the proper inflammatory milieu may provide a suitable microenvironment for neurogenesis; however, detailed mechanisms underlying the inflammatory responses that initiate or inhibit neurogenesis remain unknown. This review summarizes recent progress concerning the mechanisms involved in brain damage, repair and regeneration related to microglia/macrophage activation and phenotype transition after stroke. We also argue that future translational studies should be targeting multiple key regulating molecules to improve brain repair, which should be accompanied by the concept of a therapeutic time window for sequential therapies." @default.
• W2346184067 created "2016-06-24" @default.
• W2346184067 creator A5014701329 @default.
• W2346184067 creator A5033390666 @default.
• W2346184067 creator A5045653330 @default.
• W2346184067 date "2016-07-01" @default.
• W2346184067 modified "2023-10-16" @default.
• W2346184067 title "Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke" @default.
• W2346184067 cites W1176169503 @default.
• W2346184067 cites W1482674003 @default.
• W2346184067 cites W1494319831 @default.
• W2346184067 cites W1523775339 @default.
• W2346184067 cites W1534609954 @default.
• W2346184067 cites W1537821126 @default.
• W2346184067 cites W1566510795 @default.
• W2346184067 cites W1566609595 @default.
• W2346184067 cites W1566930200 @default.
• W2346184067 cites W1575083490 @default.
• W2346184067 cites W1592706250 @default.
• W2346184067 cites W1605844554 @default.
• W2346184067 cites W1630155892 @default.
• W2346184067 cites W1659632558 @default.
• W2346184067 cites W1677666118 @default.
• W2346184067 cites W1750541493 @default.
• W2346184067 cites W1764212712 @default.
• W2346184067 cites W1841850981 @default.
• W2346184067 cites W1857715296 @default.
• W2346184067 cites W1869691464 @default.
• W2346184067 cites W1874066939 @default.
• W2346184067 cites W1893031632 @default.
• W2346184067 cites W1894485240 @default.
• W2346184067 cites W1896283776 @default.
• W2346184067 cites W1911832415 @default.
• W2346184067 cites W1912143182 @default.
• W2346184067 cites W1917016997 @default.
• W2346184067 cites W1918411450 @default.
• W2346184067 cites W1937277400 @default.
• W2346184067 cites W1964041350 @default.
• W2346184067 cites W1964429630 @default.
• W2346184067 cites W1964733840 @default.
• W2346184067 cites W1966410297 @default.
• W2346184067 cites W1968732640 @default.
• W2346184067 cites W1969474596 @default.
• W2346184067 cites W1969789444 @default.
• W2346184067 cites W1972942987 @default.
• W2346184067 cites W1973207697 @default.
• W2346184067 cites W1973838846 @default.
• W2346184067 cites W1974134732 @default.
• W2346184067 cites W1975275391 @default.
• W2346184067 cites W1975400014 @default.
• W2346184067 cites W1975757036 @default.
• W2346184067 cites W1976589901 @default.
• W2346184067 cites W1977213877 @default.
• W2346184067 cites W1977735016 @default.
• W2346184067 cites W1978655989 @default.
• W2346184067 cites W1978927200 @default.
• W2346184067 cites W1979550370 @default.
• W2346184067 cites W1979733618 @default.
• W2346184067 cites W1980429797 @default.
• W2346184067 cites W1980789245 @default.
• W2346184067 cites W1981836314 @default.
• W2346184067 cites W1984011020 @default.
• W2346184067 cites W1984441940 @default.
• W2346184067 cites W1988178045 @default.
• W2346184067 cites W1991086765 @default.
• W2346184067 cites W1991355498 @default.
• W2346184067 cites W1992365602 @default.
• W2346184067 cites W1992808792 @default.
• W2346184067 cites W1992815041 @default.
• W2346184067 cites W1992913006 @default.
• W2346184067 cites W1994781304 @default.
• W2346184067 cites W1997089052 @default.
• W2346184067 cites W1997352049 @default.
• W2346184067 cites W1997762393 @default.
• W2346184067 cites W1998106951 @default.
• W2346184067 cites W1998773692 @default.
• W2346184067 cites W2001244796 @default.
• W2346184067 cites W2002642158 @default.
• W2346184067 cites W2003080204 @default.
• W2346184067 cites W2003438800 @default.
• W2346184067 cites W2003674452 @default.
• W2346184067 cites W2004149652 @default.
• W2346184067 cites W2004465286 @default.
• W2346184067 cites W2004750620 @default.
• W2346184067 cites W2004877451 @default.
• W2346184067 cites W2005695657 @default.
• W2346184067 cites W2006496431 @default.
• W2346184067 cites W2006885922 @default.
• W2346184067 cites W2007317274 @default.
• W2346184067 cites W2007855994 @default.
• W2346184067 cites W2008921519 @default.
• W2346184067 cites W2009170266 @default.
• W2346184067 cites W2009256046 @default.
• W2346184067 cites W2011723175 @default.
• W2346184067 cites W2012436288 @default.
• W2346184067 cites W2013005759 @default.
• W2346184067 cites W2013741161 @default.
• W2346184067 cites W2014431033 @default.

• next