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• W2346244967 endingPage "e0154684" @default.
• W2346244967 startingPage "e0154684" @default.
• W2346244967 abstract "Here, we document that persistent mitochondria DNA (mtDNA) damage due to mitochondrial overexpression of the Y147A mutant uracil-N-glycosylase as well as mitochondrial overexpression of bacterial Exonuclease III or Herpes Simplex Virus protein UL12.5M185 can induce a complete loss of mtDNA (ρ0 phenotype) without compromising the viability of cells cultured in media supplemented with uridine and pyruvate. Furthermore, we use these observations to develop rapid, sequence-independent methods for the elimination of mtDNA, and demonstrate utility of these methods for generating ρ0 cells of human, mouse and rat origin. We also demonstrate that ρ0 cells generated by each of these three methods can serve as recipients of mtDNA in fusions with enucleated cells." @default.
• W2346244967 created "2016-06-24" @default.
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• W2346244967 date "2016-05-02" @default.
• W2346244967 modified "2023-10-18" @default.
• W2346244967 title "Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells" @default.
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• W2346244967 doi "https://doi.org/10.1371/journal.pone.0154684" @default.
• W2346244967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4852919" @default.
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• W2346244967 hasPublicationYear "2016" @default.
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