Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346366513> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2346366513 endingPage "133" @default.
- W2346366513 startingPage "131" @default.
- W2346366513 abstract "Sublingual buprenorphine is indicated for opioid dependence. It comes in 2 formulations: a mono buprenorphine product (BUP) and a combination product containing naloxone (BUP-NAL), which functions as an abuse deterrent. Sublingual naloxone does not reach clinically significant levels except in cases of hepatic impairment, where its metabolism can be impaired. Substantial naloxone accumulation could block the therapeutic effects of buprenorphine. The risk of hepatic impairment is elevated in the opioid dependence population, and our case highlights the need for careful evaluation of hepatic function and consideration of BUP.We report a patient with end-stage liver disease who began BUP-NAL induction with modest improvement on treatment day 1 followed by sustained withdrawal after receiving an observed dose on day 2. He returned to the clinic 2 days after his second successive day of BUP-NAL, vomiting and complaining of persistent withdrawal. To avoid potential accumulation of naloxone, the patient was eventually switched to and stabilized on BUP with good response.The clinical course this patient experienced during induction makes a case that naloxone can accumulate and interfere with the effectiveness of buprenorphine in the presence of liver dysfunction. Our case highlights the need for consideration of BUP in circumstances where patient safety and effective treatment outweigh the risks of prescribing a product with abuse deterrent properties." @default.
- W2346366513 created "2016-06-24" @default.
- W2346366513 creator A5019436985 @default.
- W2346366513 creator A5048858371 @default.
- W2346366513 date "2016-01-01" @default.
- W2346366513 modified "2023-10-17" @default.
- W2346366513 title "Intolerance of sublingual buprenorphine-naloxone during induction in a patient with end-stage liver disease: A case report" @default.
- W2346366513 cites W1838526882 @default.
- W2346366513 cites W1977378880 @default.
- W2346366513 cites W1982786105 @default.
- W2346366513 cites W2013515770 @default.
- W2346366513 cites W2082705528 @default.
- W2346366513 cites W2089355222 @default.
- W2346366513 cites W2090204769 @default.
- W2346366513 cites W2099536555 @default.
- W2346366513 cites W2133948398 @default.
- W2346366513 cites W2152591738 @default.
- W2346366513 cites W2158102643 @default.
- W2346366513 cites W4211124708 @default.
- W2346366513 doi "https://doi.org/10.9740/mhc.2016.05.131" @default.
- W2346366513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6007647" @default.
- W2346366513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29955460" @default.
- W2346366513 hasPublicationYear "2016" @default.
- W2346366513 type Work @default.
- W2346366513 sameAs 2346366513 @default.
- W2346366513 citedByCount "3" @default.
- W2346366513 countsByYear W23463665132020 @default.
- W2346366513 countsByYear W23463665132022 @default.
- W2346366513 crossrefType "journal-article" @default.
- W2346366513 hasAuthorship W2346366513A5019436985 @default.
- W2346366513 hasAuthorship W2346366513A5048858371 @default.
- W2346366513 hasBestOaLocation W23463665131 @default.
- W2346366513 hasConcept C126322002 @default.
- W2346366513 hasConcept C170493617 @default.
- W2346366513 hasConcept C2777075537 @default.
- W2346366513 hasConcept C2778750930 @default.
- W2346366513 hasConcept C2778949969 @default.
- W2346366513 hasConcept C2779350572 @default.
- W2346366513 hasConcept C2780852908 @default.
- W2346366513 hasConcept C2781063702 @default.
- W2346366513 hasConcept C2908647359 @default.
- W2346366513 hasConcept C42219234 @default.
- W2346366513 hasConcept C71924100 @default.
- W2346366513 hasConcept C99454951 @default.
- W2346366513 hasConceptScore W2346366513C126322002 @default.
- W2346366513 hasConceptScore W2346366513C170493617 @default.
- W2346366513 hasConceptScore W2346366513C2777075537 @default.
- W2346366513 hasConceptScore W2346366513C2778750930 @default.
- W2346366513 hasConceptScore W2346366513C2778949969 @default.
- W2346366513 hasConceptScore W2346366513C2779350572 @default.
- W2346366513 hasConceptScore W2346366513C2780852908 @default.
- W2346366513 hasConceptScore W2346366513C2781063702 @default.
- W2346366513 hasConceptScore W2346366513C2908647359 @default.
- W2346366513 hasConceptScore W2346366513C42219234 @default.
- W2346366513 hasConceptScore W2346366513C71924100 @default.
- W2346366513 hasConceptScore W2346366513C99454951 @default.
- W2346366513 hasIssue "3" @default.
- W2346366513 hasLocation W23463665131 @default.
- W2346366513 hasLocation W23463665132 @default.
- W2346366513 hasLocation W23463665133 @default.
- W2346366513 hasLocation W23463665134 @default.
- W2346366513 hasOpenAccess W2346366513 @default.
- W2346366513 hasPrimaryLocation W23463665131 @default.
- W2346366513 hasRelatedWork W1975094265 @default.
- W2346366513 hasRelatedWork W1990071324 @default.
- W2346366513 hasRelatedWork W2012069003 @default.
- W2346366513 hasRelatedWork W2091295574 @default.
- W2346366513 hasRelatedWork W2119421920 @default.
- W2346366513 hasRelatedWork W2184218697 @default.
- W2346366513 hasRelatedWork W2461248502 @default.
- W2346366513 hasRelatedWork W2591252749 @default.
- W2346366513 hasRelatedWork W2911825378 @default.
- W2346366513 hasRelatedWork W3211392126 @default.
- W2346366513 hasVolume "6" @default.
- W2346366513 isParatext "false" @default.
- W2346366513 isRetracted "false" @default.
- W2346366513 magId "2346366513" @default.
- W2346366513 workType "article" @default.