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• W2346405161 abstract "Crystal structures of the reverse transcriptase domains of two group II intron–encoded proteins reveal their similarity to the RT domain of splicing factor Prp8, thus suggesting a common ancestry shared by group II introns and the spliceosome. Group II introns are self-splicing ribozymes that are essential in many organisms, and they have been hypothesized to share a common evolutionary ancestor with the spliceosome. Although structural similarity of RNA components supports this connection, it is of interest to determine whether associated protein factors also share an evolutionary heritage. Here we present the crystal structures of reverse transcriptase (RT) domains from two group II intron–encoded proteins (maturases) from Roseburia intestinalis and Eubacterium rectale, obtained at 1.2-Å and 2.1-Å resolution, respectively. These domains are more similar in architecture to the spliceosomal Prp8 RT-like domain than to any other RTs, and they share substantial similarity with flaviviral RNA polymerases. The RT domain itself is sufficient for binding intron RNA with high affinity and specificity, and it is contained within an active RT enzyme. These studies provide a foundation for understanding structure–function relationships within group II intron–maturase complexes." @default.
• W2346405161 created "2016-06-24" @default.
• W2346405161 creator A5007909912 @default.
• W2346405161 creator A5067111030 @default.
• W2346405161 date "2016-05-02" @default.
• W2346405161 modified "2023-10-10" @default.
• W2346405161 title "Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution" @default.
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• W2346405161 doi "https://doi.org/10.1038/nsmb.3224" @default.
• W2346405161 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4899126" @default.
• W2346405161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27136328" @default.
• W2346405161 hasPublicationYear "2016" @default.
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