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• W2346420742 abstract "The present study aimed to reveal the expression of STAT3 and Anxa 2 in CRC specimens and to investigate the effects of STAT3 and Anxa 2 signaling on the proliferation, invasion, and migration in CRC Caco-2 cells. Results demonstrated that both Anxa 2 and STAT3 were highly expressed in CRC specimens in both mRNA and protein levels, with or without phosphorylation (Tyrosine 23 in Anxa 2 and Tyrosine 705 in STAT3). And the upregulated Anxa 2 promoted the phosphorylation of STAT3 (Tyrosine 705) in CRC Caco-2 cells. The upregulated Anxa 2 promoted the proliferation, migration, and invasion of Caco-2 cells in vitro. Moreover, the STAT3 knockdown also repressed the proliferation, migration, and invasion of Caco-2 cells. In conclusion, the overexpressed Annexin A2 regulated the proliferation, invasion, and migration in CRC cells in an association with STAT3." @default.
• W2346420742 created "2016-06-24" @default.
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• W2346420742 date "2016-01-01" @default.
• W2346420742 modified "2023-10-17" @default.
• W2346420742 title "Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells<i>In Vitro</i>" @default.
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• W2346420742 doi "https://doi.org/10.1155/2016/3521453" @default.
• W2346420742 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4870365" @default.
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