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- W2346454802 abstract "In recent decades solid lipid nanoparticles (SLN) have become a well-performing tool for the site-targeted delivery of water-insoluble drugs. In this study, Compritol® 888 ATO-based SLN, coated with polysorbate 80, were loaded with rapamycin (Rap), a lipophilic immunomodulator, broadly-used in therapies of cancer and neurodegenerative diseases. Rap-SLN were formulated using cold high-pressure homogenization and ultrasound-assisted emulsion. The exploitation of these methods yielded the nanoparticles of various values of zeta-potential (from −1 mV to −20 mV) and efficacies of the Rap entrapment (from 37.5 ± 2.3% to 77.0 ± 5.4%). The SEM and AFM imaging and shape-modeling by the combined DLS-SANS analysis revealed that the Rap-SLN of the hydrodynamic radius of ∼46 nm preserve the platelet-like or flat ellipsoidal structure with a thickness as large as 8–9 nm. These dimensions correspond to a single lipid bilayer, organized in a triclinic Lβ polymorph, and covered with a 1–2-nm shell of the surfactant. Consistently, FT-IR spectra acquired in the range 52–75 °C, showed that the Rap incorporation within the lipid matrix decreases the point of the gel-liquid crystalline (Lβ-Lα) phase transition. These outcomes imply a thermodynamically-driven mechanism of the Rap release from SLN." @default.
- W2346454802 created "2016-06-24" @default.
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- W2346454802 date "2016-08-01" @default.
- W2346454802 modified "2023-10-18" @default.
- W2346454802 title "Rapamycin-loaded solid lipid nanoparticles: Morphology and impact of the drug loading on the phase transition between lipid polymorphs" @default.
- W2346454802 cites W1579046626 @default.
- W2346454802 cites W1968907302 @default.
- W2346454802 cites W1969080040 @default.
- W2346454802 cites W1970371242 @default.
- W2346454802 cites W1972144921 @default.
- W2346454802 cites W1975756402 @default.
- W2346454802 cites W1977532539 @default.
- W2346454802 cites W1978477577 @default.
- W2346454802 cites W1982759704 @default.
- W2346454802 cites W1984781844 @default.
- W2346454802 cites W1985139876 @default.
- W2346454802 cites W1986974569 @default.
- W2346454802 cites W1991592195 @default.
- W2346454802 cites W1994672839 @default.
- W2346454802 cites W1996590456 @default.
- W2346454802 cites W2005277819 @default.
- W2346454802 cites W2005728523 @default.
- W2346454802 cites W2005759082 @default.
- W2346454802 cites W2007099602 @default.
- W2346454802 cites W2010609050 @default.
- W2346454802 cites W2012825128 @default.
- W2346454802 cites W2014154555 @default.
- W2346454802 cites W2018504340 @default.
- W2346454802 cites W2021676537 @default.
- W2346454802 cites W2029348880 @default.
- W2346454802 cites W2032580068 @default.
- W2346454802 cites W2034082246 @default.
- W2346454802 cites W2037363639 @default.
- W2346454802 cites W2038088215 @default.
- W2346454802 cites W2040594573 @default.
- W2346454802 cites W2045390594 @default.
- W2346454802 cites W2046536977 @default.
- W2346454802 cites W2047167799 @default.
- W2346454802 cites W2049599293 @default.
- W2346454802 cites W2050147724 @default.
- W2346454802 cites W2060557807 @default.
- W2346454802 cites W2068386887 @default.
- W2346454802 cites W2068522738 @default.
- W2346454802 cites W2068778901 @default.
- W2346454802 cites W2070538463 @default.
- W2346454802 cites W2073778158 @default.
- W2346454802 cites W2074037814 @default.
- W2346454802 cites W2076174206 @default.
- W2346454802 cites W2081713406 @default.
- W2346454802 cites W2081926138 @default.
- W2346454802 cites W2083172358 @default.
- W2346454802 cites W2085692671 @default.
- W2346454802 cites W2091380836 @default.
- W2346454802 cites W2094968130 @default.
- W2346454802 cites W2095419133 @default.
- W2346454802 cites W2103082495 @default.
- W2346454802 cites W2103588625 @default.
- W2346454802 cites W2108433028 @default.
- W2346454802 cites W2112326782 @default.
- W2346454802 cites W2114190473 @default.
- W2346454802 cites W2114237009 @default.
- W2346454802 cites W2120487347 @default.
- W2346454802 cites W2134138119 @default.
- W2346454802 cites W2147134978 @default.
- W2346454802 cites W2147575825 @default.
- W2346454802 cites W2153989681 @default.
- W2346454802 cites W2160386420 @default.
- W2346454802 cites W2161051443 @default.
- W2346454802 cites W2168726127 @default.
- W2346454802 cites W230709115 @default.
- W2346454802 cites W2411417324 @default.
- W2346454802 cites W2517054293 @default.
- W2346454802 cites W37840549 @default.
- W2346454802 cites W87780399 @default.
- W2346454802 doi "https://doi.org/10.1016/j.colsurfa.2016.05.017" @default.
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