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• W2346479583 abstract "The potential of the skin immune system to generate immune responses is well established, and the skin is actively exploited as a vaccination site. Human skin contains several antigen-presenting cell subsets with specialized functions. In particular, the capacity to cross-present exogenous antigens to CD8+ T cells is of interest for the design of effective immunotherapies against viruses or cancer. Here, we show that primary human Langerhans cells (LCs) were able to cross-present a synthetic long peptide (SLP) to CD8+ T cells. In addition, modification of this SLP using antibodies against the receptor langerin, but not dectin-1, further enhanced the cross-presenting capacity of LCs through routing of internalized antigens to less proteolytic early endosome antigen 1+ early endosomes. The potency of LCs to enhance CD8+ T-cell responses could be further increased through activation of LCs with the toll-like receptor 3 ligand polyinosinic:polycytidylic acid (pI:C). Altogether, the data provide evidence that human LCs are able to cross-present antigens after langerin-mediated internalization. Furthermore, the potential for antigen modification to target LCs specifically provides a rationale for generating effective anti-tumor or anti-viral cytotoxic T lymphocyte responses." @default.
• W2346479583 created "2016-06-24" @default.
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• W2346479583 date "2015-10-12" @default.
• W2346479583 modified "2023-09-23" @default.
• W2346479583 title "Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells" @default.
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• W2346479583 doi "https://doi.org/10.1038/cmi.2015.87" @default.
• W2346479583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5380941" @default.
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• W2346479583 hasPublicationYear "2015" @default.
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