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• W2346514696 abstract "Subjective cognitive complaints (SCC) in individuals with normal performance on neuropsychological tests may be indicative of preclinical Alzheimer's disease (AD). The SCC may reflect subtle cognitive decline in patients who do not fulfil criteria for mild cognitive impairment (MCI) because of normal performance on neuropsychological tests. However, SCC may also reflect depressive symptomatology. The aim of this study was to examine the relationship between subjective cognitive complaints and cognition in patients with SCC and MCI. Seventy-five non-demented subjects referred to the Memory Clinic for SCC were classified into amnestic MCI (n=29) and SCC (n=46) groups based on clinical evaluation and complex neuropsychological assessment. The participants were administered Thirty-nine-item McNair's Cognitive Difficulties Scale (CDS) and 10-item Questionnaire de la plainte mnésique (QPM) to evaluate SCC. Geriatric depression scale (15-item version, GDS-15) was used to assess depressive symptoms. The subjects with extensive vascular changes on MRI (Fazekas > 2) and those scoring more than six points on GDS-15 and were not included. The composite scores of episodic memory, attention, working memory, executive function and language were calculated as the averages of z-scores of at least two neuropsychological tests for each cognitive domain. The total scores of QPM and CDS correlated with GDS-15 score (rhó=.425, p<.001 and rhó=.341, p=.009, respectively). There was no correlation between QPM and CDS scores and composite scores of each cognitive domain. When analyzing the QPM and CDS questions separately, several items correlated with memory, attention, working memory, executive function and language. SCC and amnestic MCI did not differ in the amount of depressive symptoms (p=.430). Currently used questionnaires of SCC seem to reflect more depressive symptomatology than cognitive impairment in patients with SCC and MCI. Detailed evaluation of specific questions may provide more valuable information on cognitive functions in SCC and MCI patients. New reliable questionnaires are needed to reflect cognitive impairment in non-demented elderly." @default.
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• W2346514696 date "2015-07-01" @default.
• W2346514696 modified "2023-09-28" @default.
• W2346514696 title "P4-113: Specific cognitive complaints are associated with objective cognitive performance" @default.
• W2346514696 doi "https://doi.org/10.1016/j.jalz.2015.06.1819" @default.
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