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- W2346534394 abstract "Abstract Private water supplies (PWS) in Cornwall, South West England exceeded the current WHO guidance value and UK prescribed concentration or value (PCV) for arsenic of 10 μg/L in 5% of properties surveyed ( n = 497). In this follow-up study, the first of its kind in the UK, volunteers ( n = 207) from 127 households who used their PWS for drinking, provided urine and drinking water samples for total As determination by inductively coupled plasma mass spectrometry (ICP-MS) and urinary As speciation by high performance liquid chromatography ICP-MS (HPLC-ICP-MS). Arsenic concentrations exceeding 10 μg/L were found in the PWS of 10% of the volunteers. Unadjusted total urinary As concentrations were poorly correlated (Spearman’s ρ = 0.36 (P < 0.001)) with PWS As largely due to the use of spot urine samples and the dominance of arsenobetaine (AB) from seafood sources. However, the osmolality adjusted sum, U-As IMM , of urinary inorganic As species, arsenite (As III ) and arsenate (As V ), and their metabolites, methylarsonate (MA) and dimethylarsinate (DMA), was found to strongly correlate (Spearman’s ρ: 0.62 (P < 0.001)) with PWS As, indicating private water supplies as the dominant source of inorganic As exposure in the study population of PWS users." @default.
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- W2346534394 date "2016-05-09" @default.
- W2346534394 modified "2023-09-26" @default.
- W2346534394 title "Urinary arsenic profiles reveal exposures to inorganic arsenic from private drinking water supplies in Cornwall, UK" @default.
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- W2346534394 doi "https://doi.org/10.1038/srep25656" @default.
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