FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346535340> ?p ?o ?g. }

• W2346535340 endingPage "1448" @default.
• W2346535340 startingPage "1438" @default.
• W2346535340 abstract "The ets transcription factor, TEL, undergoes chromosomal rearrangements with the tyrosine kinase JAK2. TEL-JAK2 is constitutively active, confers cell line factor independence, and activates signal transducer and activator of transcription-1 (STAT1), STAT3, and STAT5. Data from bone marrow transplantation models suggest that STAT5 activation does not account for the entire disease phenotype induced by TEL-JAK2. This study examined additional signaling pathways that are activated by TEL-JAK2. TEL-JAK2 expression in Ba/F3 cells results in constitutive association and tyrosine phosphorylation of Shc and Ship-1 and, consequently, recruitment of Grb2 to TEL-JAK2. Direct Grb2 recruitment is also possible because a putative Grb2 binding site, Tyr314, is present on TEL-JAK2(5-19) and TEL-JAK2(5-12). Studies with a TEL-JAK2(5-19)Tyr314Phe mutant support a role for Tyr314 in Grb2 recruitment, because Grb2 association with TEL-JAK2(5-19)Tyr314Phe is significantly reduced. Interestingly, TEL-JAK2(5-19)Tyr314Phe shows reduced Ras activation when compared with TEL-JAK2(4-17), TEL-JAK2(5-12), and TEL-JAK2(5-19). Analysis of extracellular signal–regulated kinase-1/2 (ERK1/2), stress-activated protein/Jun kinase (SAPK/JNK), and p38 demonstrates the activation of SAPK/JNK and phosphorylation of p38 by all TEL-JAK2 isoforms. TEL-JAK2(5-12) and TEL-JAK2(5-19) preferentially phosphorylate ERK2, whereas TEL-JAK2(4-17) phosphorylated ERK2 at lower levels. Inhibition studies demonstrated that ERK1/2 activation was necessary for Ba/F3 factor independence mediated by TEL-JAK2(5-19), while inhibition of SAPK/JNK or p38 activity had no effect. Our data reveal the requirement of ERK activation by TEL-JAK2(5-19) in Ba/F3 cells and suggest that TEL-JAK2 leukemogenic potential may be mediated in part through ERK1/2." @default.
• W2346535340 created "2016-06-24" @default.
• W2346535340 creator A5014738261 @default.
• W2346535340 creator A5021734071 @default.
• W2346535340 creator A5032477226 @default.
• W2346535340 creator A5040255318 @default.
• W2346535340 creator A5042390536 @default.
• W2346535340 creator A5049759278 @default.
• W2346535340 creator A5064051016 @default.
• W2346535340 creator A5071547412 @default.
• W2346535340 creator A5076871248 @default.
• W2346535340 creator A5091053901 @default.
• W2346535340 date "2002-08-15" @default.
• W2346535340 modified "2023-09-27" @default.
• W2346535340 title "TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways." @default.
• W2346535340 cites W10844420 @default.
• W2346535340 cites W1495797510 @default.
• W2346535340 cites W1520290955 @default.
• W2346535340 cites W1559197668 @default.
• W2346535340 cites W1576975148 @default.
• W2346535340 cites W1591823948 @default.
• W2346535340 cites W1593199101 @default.
• W2346535340 cites W1672882868 @default.
• W2346535340 cites W170428794 @default.
• W2346535340 cites W1719330231 @default.
• W2346535340 cites W195552824 @default.
• W2346535340 cites W1971475788 @default.
• W2346535340 cites W1971997730 @default.
• W2346535340 cites W1976059757 @default.
• W2346535340 cites W1980981080 @default.
• W2346535340 cites W1985782864 @default.
• W2346535340 cites W1989710374 @default.
• W2346535340 cites W199333423 @default.
• W2346535340 cites W1993664053 @default.
• W2346535340 cites W1995539779 @default.
• W2346535340 cites W2000269495 @default.
• W2346535340 cites W2002377159 @default.
• W2346535340 cites W2006147172 @default.
• W2346535340 cites W2006917576 @default.
• W2346535340 cites W2008008296 @default.
• W2346535340 cites W2012766600 @default.
• W2346535340 cites W2021904192 @default.
• W2346535340 cites W2022526006 @default.
• W2346535340 cites W2026403124 @default.
• W2346535340 cites W2033817976 @default.
• W2346535340 cites W2034393294 @default.
• W2346535340 cites W2036180570 @default.
• W2346535340 cites W2038579579 @default.
• W2346535340 cites W2047398915 @default.
• W2346535340 cites W2058924545 @default.
• W2346535340 cites W2059059532 @default.
• W2346535340 cites W2059664449 @default.
• W2346535340 cites W2065630930 @default.
• W2346535340 cites W2069023125 @default.
• W2346535340 cites W2081638226 @default.
• W2346535340 cites W2087985781 @default.
• W2346535340 cites W2089889881 @default.
• W2346535340 cites W2100740895 @default.
• W2346535340 cites W2103454230 @default.
• W2346535340 cites W2104485296 @default.
• W2346535340 cites W2105533439 @default.
• W2346535340 cites W2116396726 @default.
• W2346535340 cites W2122883220 @default.
• W2346535340 cites W2123070759 @default.
• W2346535340 cites W2127227377 @default.
• W2346535340 cites W2133013399 @default.
• W2346535340 cites W2133124453 @default.
• W2346535340 cites W2133396287 @default.
• W2346535340 cites W2134582745 @default.
• W2346535340 cites W2138807703 @default.
• W2346535340 cites W2142962849 @default.
• W2346535340 cites W2146573379 @default.
• W2346535340 cites W2153909637 @default.
• W2346535340 cites W2156568059 @default.
• W2346535340 cites W2159371111 @default.
• W2346535340 cites W2165023381 @default.
• W2346535340 cites W2176845974 @default.
• W2346535340 cites W2278462616 @default.
• W2346535340 cites W2303212700 @default.
• W2346535340 cites W2340214166 @default.
• W2346535340 cites W2398939307 @default.
• W2346535340 cites W2403474134 @default.
• W2346535340 cites W2403975263 @default.
• W2346535340 cites W2409920262 @default.
• W2346535340 cites W2414886680 @default.
• W2346535340 cites W324549396 @default.
• W2346535340 cites W50290146 @default.
• W2346535340 cites W70077809 @default.
• W2346535340 cites W7145377 @default.
• W2346535340 cites W97463986 @default.
• W2346535340 doi "https://doi.org/10.1182/blood.v100.4.1438.h81602001438_1438_1448" @default.
• W2346535340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12149229" @default.
• W2346535340 hasPublicationYear "2002" @default.
• W2346535340 type Work @default.
• W2346535340 sameAs 2346535340 @default.
• W2346535340 citedByCount "9" @default.
• W2346535340 countsByYear W23465353402012 @default.
• W2346535340 countsByYear W23465353402015 @default.

• next