FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346538863> ?p ?o ?g. }

• W2346538863 endingPage "905" @default.
• W2346538863 startingPage "893" @default.
• W2346538863 abstract "Dopamine has been implicated in the regulation of sleep–wake states and the circadian rhythm. However, there is no consensus on the impact of two established dopaminergic gene variants: the catechol-O-methyltransferase Val158Met (COMT Val158Met; rs4680) and the dopamine D4 receptor Exon III variable-number-of-tandem-repeat polymorphism (DRD4 VNTR). Pursuing a multi-method approach, we examined their potential effects on circadian preferences, arousal regulation and sleep. Subjects underwent a 7-day actigraphy assessment (SenseWear Pro3), a 20-minute resting EEG (analyzed using VIGALL 2.0) and a body mass index (BMI) assessment. Further, they completed the Morningness–Eveningness Questionnaire (MEQ), the Epworth Sleepiness Scale (ESS) and the Pittsburgh Sleep Quality Index (PSQI). The sample comprised 4625 subjects (19–82 years) genotyped for COMT Val158Met, and 689 elderly subjects (64–82 years) genotyped for DRD4 VNTR. The number of subjects varied across phenotypes. Power calculations revealed a minimum required phenotypic variance explained by genotype ranging between 0.5% and 1.5% for COMT Val158Met and between 3.3% and 6.0% for DRD4 VNTR. Analyses did not reveal significant genotype effects on MEQ, ESS, PSQI, BMI, actigraphy and EEG variables. Additionally, we found no compelling evidence in sex- and age-stratified subsamples. Few associations surpassed the threshold of nominal significance (p < .05), providing some indication for a link between DRD4 VNTR and daytime sleepiness. Taken together, in light of the statistical power obtained in the present study, our data particularly suggest no impact of the COMT Val158Met polymorphism on circadian preferences, arousal regulation and sleep. The suggestive link between DRD4 VNTR and daytime sleepiness, on the other hand, might be worth investigation in a sample enriched with younger adults." @default.
• W2346538863 created "2016-06-24" @default.
• W2346538863 creator A5004111659 @default.
• W2346538863 creator A5010965658 @default.
• W2346538863 creator A5014078626 @default.
• W2346538863 creator A5022779311 @default.
• W2346538863 creator A5030440352 @default.
• W2346538863 creator A5037117313 @default.
• W2346538863 creator A5041761080 @default.
• W2346538863 creator A5052406122 @default.
• W2346538863 creator A5052673298 @default.
• W2346538863 creator A5055628127 @default.
• W2346538863 creator A5064639395 @default.
• W2346538863 creator A5073349248 @default.
• W2346538863 creator A5090299208 @default.
• W2346538863 date "2016-05-05" @default.
• W2346538863 modified "2023-09-23" @default.
• W2346538863 title "Time to wake up: No impact of COMT Val158Met gene variation on circadian preferences, arousal regulation and sleep" @default.
• W2346538863 cites W1410533246 @default.
• W2346538863 cites W1538619854 @default.
• W2346538863 cites W1584047372 @default.
• W2346538863 cites W1588434295 @default.
• W2346538863 cites W1606608030 @default.
• W2346538863 cites W1870939480 @default.
• W2346538863 cites W197066864 @default.
• W2346538863 cites W1971228815 @default.
• W2346538863 cites W1971952979 @default.
• W2346538863 cites W1977869470 @default.
• W2346538863 cites W1978592880 @default.
• W2346538863 cites W1979369962 @default.
• W2346538863 cites W1982514353 @default.
• W2346538863 cites W1986348806 @default.
• W2346538863 cites W1995200202 @default.
• W2346538863 cites W1995937571 @default.
• W2346538863 cites W1995992264 @default.
• W2346538863 cites W1996550713 @default.
• W2346538863 cites W1997985406 @default.
• W2346538863 cites W1998599506 @default.
• W2346538863 cites W1998670974 @default.
• W2346538863 cites W2002056694 @default.
• W2346538863 cites W2003101849 @default.
• W2346538863 cites W2010014315 @default.
• W2346538863 cites W2013225028 @default.
• W2346538863 cites W2019748346 @default.
• W2346538863 cites W2021203820 @default.
• W2346538863 cites W2033370173 @default.
• W2346538863 cites W2039153962 @default.
• W2346538863 cites W2043226349 @default.
• W2346538863 cites W2054251181 @default.
• W2346538863 cites W2054856852 @default.
• W2346538863 cites W2059241370 @default.
• W2346538863 cites W2062883133 @default.
• W2346538863 cites W2065458131 @default.
• W2346538863 cites W2067901474 @default.
• W2346538863 cites W2069394061 @default.
• W2346538863 cites W2077343081 @default.
• W2346538863 cites W2078189712 @default.
• W2346538863 cites W2086710797 @default.
• W2346538863 cites W2086783442 @default.
• W2346538863 cites W2087484885 @default.
• W2346538863 cites W208904149 @default.
• W2346538863 cites W2090383555 @default.
• W2346538863 cites W2094347374 @default.
• W2346538863 cites W2100961702 @default.
• W2346538863 cites W2103612899 @default.
• W2346538863 cites W2107755054 @default.
• W2346538863 cites W2110897038 @default.
• W2346538863 cites W2111381386 @default.
• W2346538863 cites W2113206834 @default.
• W2346538863 cites W2130455745 @default.
• W2346538863 cites W2134942844 @default.
• W2346538863 cites W2141872124 @default.
• W2346538863 cites W2146392036 @default.
• W2346538863 cites W2151189356 @default.
• W2346538863 cites W2151487996 @default.
• W2346538863 cites W2153792505 @default.
• W2346538863 cites W2154201503 @default.
• W2346538863 cites W2158129434 @default.
• W2346538863 cites W2267729066 @default.
• W2346538863 cites W2292428495 @default.
• W2346538863 cites W2413519360 @default.
• W2346538863 cites W4301029050 @default.
• W2346538863 doi "https://doi.org/10.1080/07420528.2016.1178275" @default.
• W2346538863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27148829" @default.
• W2346538863 hasPublicationYear "2016" @default.
• W2346538863 type Work @default.
• W2346538863 sameAs 2346538863 @default.
• W2346538863 citedByCount "19" @default.
• W2346538863 countsByYear W23465388632016 @default.
• W2346538863 countsByYear W23465388632017 @default.
• W2346538863 countsByYear W23465388632018 @default.
• W2346538863 countsByYear W23465388632019 @default.
• W2346538863 countsByYear W23465388632020 @default.
• W2346538863 countsByYear W23465388632021 @default.
• W2346538863 countsByYear W23465388632022 @default.
• W2346538863 countsByYear W23465388632023 @default.
• W2346538863 crossrefType "journal-article" @default.
• W2346538863 hasAuthorship W2346538863A5004111659 @default.

• next