FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346567426> ?p ?o ?g. }

• W2346567426 endingPage "371" @default.
• W2346567426 startingPage "363" @default.
• W2346567426 abstract "Although Ki67 index suffers from poor reproducibility, it is one of the most important prognostic markers used by oncologists to select the treatment of estrogen receptor (ER) positive breast cancer patients. In this study, we aim to establish the optimal Ki67 cut-offs for stratifying patient prognosis and to create a comprehensive prognostic index for clinical applications. A mono-institutional cohort of 1.577 human epidermal growth factor receptor 2 negative/ER+ breast cancer patients having complete clinical, histological, and follow-up data was collected. The 14 and 20 % Ki67 cut-offs were correlated to disease-free interval (DFI) and disease-specific survival (DSS). To create a comprehensive prognostic index, we used independent variables selected by uni/multivariate analyses. In terms of DFI and DSS, patients bearing tumors with Ki67 < 14 % proliferation index did not differ from those with Ki67 values between 14 and 20 %. Patients with tumor with Ki67 > 20 % showed the poorest prognosis. Moreover, to tumor size, the number of metastatic lymph nodes and Ki67 > 20 % was given a score value, varying depending on definite cut-offs and used to create a prognostic index, which was applied to the population. Patients with a prognostic index ≥3 were characterized by significant risk of relapse [DFI: Hazard Ratio (HR) = 4.74, p < 0.001] and death (DSS: HR = 5.03, p < 0.001). We confirm that the 20 % Ki67 cut-off is the best to stratify high-risk patients in luminal breast cancers, and we suggest to integrate it with other prognostic factors, to better stratify patients at risk of adverse outcome." @default.
• W2346567426 created "2016-06-24" @default.
• W2346567426 creator A5019107001 @default.
• W2346567426 creator A5026006211 @default.
• W2346567426 creator A5029036674 @default.
• W2346567426 creator A5045011793 @default.
• W2346567426 creator A5049022619 @default.
• W2346567426 creator A5057001950 @default.
• W2346567426 creator A5068131767 @default.
• W2346567426 creator A5069076188 @default.
• W2346567426 creator A5089164502 @default.
• W2346567426 date "2016-05-07" @default.
• W2346567426 modified "2023-10-10" @default.
• W2346567426 title "Optimal Ki67 cut-off for luminal breast cancer prognostic evaluation: a large case series study with a long-term follow-up" @default.
• W2346567426 cites W134095429 @default.
• W2346567426 cites W1997852391 @default.
• W2346567426 cites W2001968322 @default.
• W2346567426 cites W2007571389 @default.
• W2346567426 cites W2013301155 @default.
• W2346567426 cites W2044702943 @default.
• W2346567426 cites W2067459683 @default.
• W2346567426 cites W2070476752 @default.
• W2346567426 cites W2074820139 @default.
• W2346567426 cites W2075664235 @default.
• W2346567426 cites W2085860544 @default.
• W2346567426 cites W2095861620 @default.
• W2346567426 cites W2117775530 @default.
• W2346567426 cites W2127057139 @default.
• W2346567426 cites W2132893003 @default.
• W2346567426 cites W2143107687 @default.
• W2346567426 cites W2144535237 @default.
• W2346567426 cites W2148819772 @default.
• W2346567426 cites W2150134401 @default.
• W2346567426 cites W2157706516 @default.
• W2346567426 cites W2159489835 @default.
• W2346567426 cites W2159955092 @default.
• W2346567426 cites W2173858545 @default.
• W2346567426 doi "https://doi.org/10.1007/s10549-016-3817-9" @default.
• W2346567426 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4875067" @default.
• W2346567426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27155668" @default.
• W2346567426 hasPublicationYear "2016" @default.
• W2346567426 type Work @default.
• W2346567426 sameAs 2346567426 @default.
• W2346567426 citedByCount "137" @default.
• W2346567426 countsByYear W23465674262016 @default.
• W2346567426 countsByYear W23465674262017 @default.
• W2346567426 countsByYear W23465674262018 @default.
• W2346567426 countsByYear W23465674262019 @default.
• W2346567426 countsByYear W23465674262020 @default.
• W2346567426 countsByYear W23465674262021 @default.
• W2346567426 countsByYear W23465674262022 @default.
• W2346567426 countsByYear W23465674262023 @default.
• W2346567426 crossrefType "journal-article" @default.
• W2346567426 hasAuthorship W2346567426A5019107001 @default.
• W2346567426 hasAuthorship W2346567426A5026006211 @default.
• W2346567426 hasAuthorship W2346567426A5029036674 @default.
• W2346567426 hasAuthorship W2346567426A5045011793 @default.
• W2346567426 hasAuthorship W2346567426A5049022619 @default.
• W2346567426 hasAuthorship W2346567426A5057001950 @default.
• W2346567426 hasAuthorship W2346567426A5068131767 @default.
• W2346567426 hasAuthorship W2346567426A5069076188 @default.
• W2346567426 hasAuthorship W2346567426A5089164502 @default.
• W2346567426 hasBestOaLocation W23465674261 @default.
• W2346567426 hasConcept C121608353 @default.
• W2346567426 hasConcept C126322002 @default.
• W2346567426 hasConcept C143998085 @default.
• W2346567426 hasConcept C204232928 @default.
• W2346567426 hasConcept C207103383 @default.
• W2346567426 hasConcept C2779134260 @default.
• W2346567426 hasConcept C2779740036 @default.
• W2346567426 hasConcept C2908647359 @default.
• W2346567426 hasConcept C2910938049 @default.
• W2346567426 hasConcept C38180746 @default.
• W2346567426 hasConcept C44249647 @default.
• W2346567426 hasConcept C50382708 @default.
• W2346567426 hasConcept C530470458 @default.
• W2346567426 hasConcept C71924100 @default.
• W2346567426 hasConcept C72563966 @default.
• W2346567426 hasConcept C84606932 @default.
• W2346567426 hasConcept C98717036 @default.
• W2346567426 hasConcept C99454951 @default.
• W2346567426 hasConceptScore W2346567426C121608353 @default.
• W2346567426 hasConceptScore W2346567426C126322002 @default.
• W2346567426 hasConceptScore W2346567426C143998085 @default.
• W2346567426 hasConceptScore W2346567426C204232928 @default.
• W2346567426 hasConceptScore W2346567426C207103383 @default.
• W2346567426 hasConceptScore W2346567426C2779134260 @default.
• W2346567426 hasConceptScore W2346567426C2779740036 @default.
• W2346567426 hasConceptScore W2346567426C2908647359 @default.
• W2346567426 hasConceptScore W2346567426C2910938049 @default.
• W2346567426 hasConceptScore W2346567426C38180746 @default.
• W2346567426 hasConceptScore W2346567426C44249647 @default.
• W2346567426 hasConceptScore W2346567426C50382708 @default.
• W2346567426 hasConceptScore W2346567426C530470458 @default.
• W2346567426 hasConceptScore W2346567426C71924100 @default.
• W2346567426 hasConceptScore W2346567426C72563966 @default.
• W2346567426 hasConceptScore W2346567426C84606932 @default.
• W2346567426 hasConceptScore W2346567426C98717036 @default.

• next