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- W2346724312 abstract "Cichlid fishes are an ideal model system for studying biological diversification because they provide textbook examples of rapid speciation. To date, there has been little focus on the role of gene regulation during cichlid speciation. However, in recent years, gene regulation has been recognized as a powerful force linking diversification in gene function to speciation. Here, we investigated the potential role of miRNA regulation in the diversification of six cichlid species of the Midas cichlid lineage (Amphilophus spp.) inhabiting the Nicaraguan crater lakes. Using several genomic resources, we inferred 236 Midas miRNA genes that were used to predict the miRNA target sites on 8,232 Midas 3'-UTRs. Using population genomic calculations of SNP diversity, we found the miRNA genes to be more conserved than protein coding genes. In contrast to what has been observed in other cichlid fish, but similar to what has been typically found in other groups, we observed genomic signatures of purifying selection on the miRNA targets by comparing these sites with the less conserved nontarget portion of the 3'-UTRs. However, in one species pair that has putatively speciated sympatrically in crater Lake Apoyo, we recovered a different pattern of relaxed purifying selection and high genetic divergence at miRNA targets. Our results suggest that sequence evolution at miRNA binding sites could be a critical genomic mechanism contributing to the rapid phenotypic evolution of Midas cichlids." @default.
- W2346724312 created "2016-06-24" @default.
- W2346724312 creator A5002887185 @default.
- W2346724312 creator A5003593150 @default.
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- W2346724312 creator A5041529580 @default.
- W2346724312 date "2016-05-01" @default.
- W2346724312 modified "2023-10-11" @default.
- W2346724312 title "The Role of microRNAs in the Repeated Parallel Diversification of Lineages of Midas Cichlid Fish from Nicaragua" @default.
- W2346724312 cites W144423133 @default.
- W2346724312 cites W1964587468 @default.
- W2346724312 cites W1968008181 @default.
- W2346724312 cites W1968376884 @default.
- W2346724312 cites W1974507358 @default.
- W2346724312 cites W1975002897 @default.
- W2346724312 cites W1984936387 @default.
- W2346724312 cites W1989827688 @default.
- W2346724312 cites W1992993799 @default.
- W2346724312 cites W1994955065 @default.
- W2346724312 cites W1997535872 @default.
- W2346724312 cites W2001157929 @default.
- W2346724312 cites W2002506897 @default.
- W2346724312 cites W2002678450 @default.
- W2346724312 cites W2006247279 @default.
- W2346724312 cites W2007579824 @default.
- W2346724312 cites W2010916267 @default.
- W2346724312 cites W2012815525 @default.
- W2346724312 cites W2013868665 @default.
- W2346724312 cites W2017426710 @default.
- W2346724312 cites W2022366061 @default.
- W2346724312 cites W2022774656 @default.
- W2346724312 cites W2023348906 @default.
- W2346724312 cites W2026570544 @default.
- W2346724312 cites W2027762384 @default.
- W2346724312 cites W2038382815 @default.
- W2346724312 cites W2038455336 @default.
- W2346724312 cites W2038584294 @default.
- W2346724312 cites W2042521784 @default.
- W2346724312 cites W2046108663 @default.
- W2346724312 cites W2066908868 @default.
- W2346724312 cites W2071925802 @default.
- W2346724312 cites W2083778040 @default.
- W2346724312 cites W2090219560 @default.
- W2346724312 cites W2093522054 @default.
- W2346724312 cites W2097065948 @default.
- W2346724312 cites W2099020875 @default.
- W2346724312 cites W2100679531 @default.
- W2346724312 cites W2102619694 @default.
- W2346724312 cites W2104005232 @default.
- W2346724312 cites W2105679485 @default.
- W2346724312 cites W2106363920 @default.
- W2346724312 cites W2106678197 @default.
- W2346724312 cites W2108234281 @default.
- W2346724312 cites W2110873353 @default.
- W2346724312 cites W2112192177 @default.
- W2346724312 cites W2117391818 @default.
- W2346724312 cites W2118837208 @default.
- W2346724312 cites W2119263996 @default.
- W2346724312 cites W2120456037 @default.
- W2346724312 cites W2123957884 @default.
- W2346724312 cites W2125126554 @default.
- W2346724312 cites W2126419817 @default.
- W2346724312 cites W2127957940 @default.
- W2346724312 cites W2128969076 @default.
- W2346724312 cites W2131271579 @default.
- W2346724312 cites W2131431511 @default.
- W2346724312 cites W2134484537 @default.
- W2346724312 cites W2134975289 @default.
- W2346724312 cites W2141157874 @default.
- W2346724312 cites W2141458291 @default.
- W2346724312 cites W2141677788 @default.
- W2346724312 cites W2148491022 @default.
- W2346724312 cites W2148581571 @default.
- W2346724312 cites W2150131459 @default.
- W2346724312 cites W2151922790 @default.
- W2346724312 cites W2154635002 @default.
- W2346724312 cites W2157876956 @default.
- W2346724312 cites W2161950199 @default.
- W2346724312 cites W2165933771 @default.
- W2346724312 cites W2167223656 @default.
- W2346724312 cites W2167639697 @default.
- W2346724312 cites W2168133698 @default.
- W2346724312 cites W2169060245 @default.
- W2346724312 cites W2170551349 @default.
- W2346724312 cites W2170831380 @default.
- W2346724312 cites W2171193618 @default.
- W2346724312 cites W2180876606 @default.
- W2346724312 cites W4230266413 @default.
- W2346724312 cites W4236236547 @default.
- W2346724312 doi "https://doi.org/10.1093/gbe/evw097" @default.
- W2346724312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4898811" @default.
- W2346724312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27189980" @default.
- W2346724312 hasPublicationYear "2016" @default.
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