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- W2346724664 abstract "Springer-Verlag 2012 Abstract Plasma concentrations of Ab40 and Ab42 rise with age and are increased in people with mutations that cause early-onset Alzheimer's disease (AD). Amyloid beta (Ab) plasma levels were successfully used as an (endo)phenotype for gene discovery using a linkage approach in families with dominant forms of disease. Here, we searched for loci involved in Ab plasma levels in a series of non-demented patients with hypertension in the Erasmus Rucphen Family study. Ab40 and Ab42 levels were determined in 125 subjects with severe hypertension. All patients were genotyped with a 6,000 single nucleotide polymorphisms (SNPs) illumina array designed for linkage analysis. We conducted linkage analysis of plasma Ab levels. None of the linkage analyses yielded genome-wide significant logarithm of odds (LOD) score over 3.3, but there was suggestive evidence for linkage" @default.
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- W2346724664 date "2012-01-01" @default.
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- W2346724664 title "Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Ab-40 levels to presenilin 2 Carla A. Ibrahim-VerbaasIrina V. ZorkoltsevaNajaf AminMaaike SchuurAntonia M. W. Coppus • Aaron IsaacsYurii S. AulchenkoMonique M. B. BretelerM. Arfan IkramTatiana I. Axenovich • Marcel M. VerbeekJohn C. van SwietenBen A. OostraCornelia M. van Duijn" @default.
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