FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346775265> ?p ?o ?g. }

• W2346775265 abstract "Drug resistance to tyrosine kinase inhibitor (TKI) is the main obstacle for efficient treatment of epidermal growth factor receptor (EGFR)-mutant lung cancer patients. Here we design a cetuximab-capped mesoporous silica nanoparticle (MP-SiO2 NP) as the drug carrier to specifically target EGFR-mutant lung cancer cells and efficiently release loaded drugs including doxorubicin and gefitinib. This innovative nano-medicine can specifically target lung cancer cells with high EGFR expression rather than those with low EGFR level. Treatment of a gefitinib-resistant cell line derived from PC9 cell (PC9-DR) with the gefitinib-loaded cetuximab-capped MP-SiO2 NP showed a significant inhibition of cell growth. Moreover, this nano-medicine successfully suppressed the progression of PC9-DR xenograft tumors. This tumor suppression was due to the endocytosis of large amount of nano-medicine and the effective gefitinib release induced by high glutathione (GSH) level in PC9-DR cells. Collectively, our study provides a novel approach to overcome EGFR-TKI resistance using cetuximab modified MP-SiO2 NP, which holds strong potential for effective management of EGFR-mutant lung cancer." @default.
• W2346775265 created "2016-06-24" @default.
• W2346775265 creator A5006210427 @default.
• W2346775265 creator A5007609180 @default.
• W2346775265 creator A5027663268 @default.
• W2346775265 creator A5057369590 @default.
• W2346775265 creator A5070514605 @default.
• W2346775265 date "2016-05-06" @default.
• W2346775265 modified "2023-10-13" @default.
• W2346775265 title "Cetuximab-modified mesoporous silica nano-medicine specifically targets EGFR-mutant lung cancer and overcomes drug resistance" @default.
• W2346775265 cites W1963539487 @default.
• W2346775265 cites W1973998725 @default.
• W2346775265 cites W1974024530 @default.
• W2346775265 cites W1976893205 @default.
• W2346775265 cites W1981053807 @default.
• W2346775265 cites W1983466982 @default.
• W2346775265 cites W1986293641 @default.
• W2346775265 cites W2014187999 @default.
• W2346775265 cites W2014956732 @default.
• W2346775265 cites W2021385919 @default.
• W2346775265 cites W2027382023 @default.
• W2346775265 cites W2030440427 @default.
• W2346775265 cites W2050476893 @default.
• W2346775265 cites W2065432613 @default.
• W2346775265 cites W2070011883 @default.
• W2346775265 cites W2073166200 @default.
• W2346775265 cites W2082526460 @default.
• W2346775265 cites W2097320192 @default.
• W2346775265 cites W2103198231 @default.
• W2346775265 cites W2119642652 @default.
• W2346775265 cites W2123714741 @default.
• W2346775265 cites W2129128202 @default.
• W2346775265 cites W2132316499 @default.
• W2346775265 cites W2136510151 @default.
• W2346775265 cites W2141630197 @default.
• W2346775265 cites W2145828709 @default.
• W2346775265 cites W2153398411 @default.
• W2346775265 cites W2154310160 @default.
• W2346775265 cites W2158155063 @default.
• W2346775265 cites W2161821474 @default.
• W2346775265 cites W2166921416 @default.
• W2346775265 cites W2167577902 @default.
• W2346775265 cites W2235523093 @default.
• W2346775265 cites W2315057398 @default.
• W2346775265 doi "https://doi.org/10.1038/srep25468" @default.
• W2346775265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4858690" @default.
• W2346775265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27151505" @default.
• W2346775265 hasPublicationYear "2016" @default.
• W2346775265 type Work @default.
• W2346775265 sameAs 2346775265 @default.
• W2346775265 citedByCount "41" @default.
• W2346775265 countsByYear W23467752652016 @default.
• W2346775265 countsByYear W23467752652017 @default.
• W2346775265 countsByYear W23467752652018 @default.
• W2346775265 countsByYear W23467752652019 @default.
• W2346775265 countsByYear W23467752652020 @default.
• W2346775265 countsByYear W23467752652021 @default.
• W2346775265 countsByYear W23467752652022 @default.
• W2346775265 countsByYear W23467752652023 @default.
• W2346775265 crossrefType "journal-article" @default.
• W2346775265 hasAuthorship W2346775265A5006210427 @default.
• W2346775265 hasAuthorship W2346775265A5007609180 @default.
• W2346775265 hasAuthorship W2346775265A5027663268 @default.
• W2346775265 hasAuthorship W2346775265A5057369590 @default.
• W2346775265 hasAuthorship W2346775265A5070514605 @default.
• W2346775265 hasBestOaLocation W23467752651 @default.
• W2346775265 hasConcept C121608353 @default.
• W2346775265 hasConcept C126322002 @default.
• W2346775265 hasConcept C143998085 @default.
• W2346775265 hasConcept C185592680 @default.
• W2346775265 hasConcept C2776256026 @default.
• W2346775265 hasConcept C2777506169 @default.
• W2346775265 hasConcept C2778087573 @default.
• W2346775265 hasConcept C2779438470 @default.
• W2346775265 hasConcept C2779998722 @default.
• W2346775265 hasConcept C2780580887 @default.
• W2346775265 hasConcept C502942594 @default.
• W2346775265 hasConcept C526805850 @default.
• W2346775265 hasConcept C71924100 @default.
• W2346775265 hasConcept C98274493 @default.
• W2346775265 hasConceptScore W2346775265C121608353 @default.
• W2346775265 hasConceptScore W2346775265C126322002 @default.
• W2346775265 hasConceptScore W2346775265C143998085 @default.
• W2346775265 hasConceptScore W2346775265C185592680 @default.
• W2346775265 hasConceptScore W2346775265C2776256026 @default.
• W2346775265 hasConceptScore W2346775265C2777506169 @default.
• W2346775265 hasConceptScore W2346775265C2778087573 @default.
• W2346775265 hasConceptScore W2346775265C2779438470 @default.
• W2346775265 hasConceptScore W2346775265C2779998722 @default.
• W2346775265 hasConceptScore W2346775265C2780580887 @default.
• W2346775265 hasConceptScore W2346775265C502942594 @default.
• W2346775265 hasConceptScore W2346775265C526805850 @default.
• W2346775265 hasConceptScore W2346775265C71924100 @default.
• W2346775265 hasConceptScore W2346775265C98274493 @default.
• W2346775265 hasIssue "1" @default.
• W2346775265 hasLocation W23467752651 @default.
• W2346775265 hasLocation W23467752652 @default.
• W2346775265 hasLocation W23467752653 @default.
• W2346775265 hasLocation W23467752654 @default.
• W2346775265 hasOpenAccess W2346775265 @default.

• next