FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346779129> ?p ?o ?g. }

• W2346779129 endingPage "10061" @default.
• W2346779129 startingPage "10057" @default.
• W2346779129 abstract "Colorectal cancer (CRC) is fourth most common cancer in men and third in women worldwide. Developing a diagnostic panel of sensitive and specific biomarkers for the early detection of CRC is recognised as to be crucial for early initial diagnosis, which in turn leads to better long term survival. Most of the research on novel potential CRC biomarkers in the last 2 decades has been focussed on stool DNA analysis. In this paper, we describe the recent advances in non-invasive CRC screening and more specifically in molecular assays for aberrantly methylated BMP3 and NDRG4 promoter regions. In several research papers these markers showed superior rates for sensitivity and specificity in comparison to previously described assays. These tests detected the majority of adenomas ≥ 1 cm in size and the detection rates progressively increased with larger adenomas. The methylation status of the BMP3 and NDRG4 promoters demonstrated effective detection of neoplasms at all sites throughout the colon and was not affected by common clinical variables. Recently, a multitarget stool DNA test consisting of molecular assays for aberrantly methylated BMP3 and NDRG4 promoter regions, mutant KRAS and immunochemical assay for human haemoglobin has been made commercially available and is currently reimbursed in the United States. Although this is the most sensitive non-invasive CRC screening test, there is the need for further research in several areas - establishment of the best timeframe for repeated DNA stool testing; validation of the results in populations outside of North America; usefulness for surveillance and prognosis of patients; cost-effectiveness of DNA stool testing in real-life populations." @default.
• W2346779129 created "2016-06-24" @default.
• W2346779129 creator A5009608111 @default.
• W2346779129 creator A5068234373 @default.
• W2346779129 date "2015-09-21" @default.
• W2346779129 modified "2023-10-02" @default.
• W2346779129 title "Stool DNA methylation assays in colorectal cancer screening" @default.
• W2346779129 cites W1496813080 @default.
• W2346779129 cites W1558105426 @default.
• W2346779129 cites W1972537482 @default.
• W2346779129 cites W1974751993 @default.
• W2346779129 cites W1981192430 @default.
• W2346779129 cites W1984646383 @default.
• W2346779129 cites W1986399343 @default.
• W2346779129 cites W1994944692 @default.
• W2346779129 cites W1997832856 @default.
• W2346779129 cites W2009575643 @default.
• W2346779129 cites W2048359072 @default.
• W2346779129 cites W2057160014 @default.
• W2346779129 cites W2066406304 @default.
• W2346779129 cites W2073160021 @default.
• W2346779129 cites W2076294405 @default.
• W2346779129 cites W2089159312 @default.
• W2346779129 cites W2097296284 @default.
• W2346779129 cites W2099828433 @default.
• W2346779129 cites W2101007892 @default.
• W2346779129 cites W2117957930 @default.
• W2346779129 cites W2137888576 @default.
• W2346779129 cites W2147072570 @default.
• W2346779129 cites W2147297736 @default.
• W2346779129 cites W2156898371 @default.
• W2346779129 cites W2157609868 @default.
• W2346779129 cites W2163054923 @default.
• W2346779129 cites W2163214467 @default.
• W2346779129 cites W2164862736 @default.
• W2346779129 cites W2167929119 @default.
• W2346779129 cites W2170552969 @default.
• W2346779129 doi "https://doi.org/10.3748/wjg.v21.i35.10057" @default.
• W2346779129 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4572786" @default.
• W2346779129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26401070" @default.
• W2346779129 hasPublicationYear "2015" @default.
• W2346779129 type Work @default.
• W2346779129 sameAs 2346779129 @default.
• W2346779129 citedByCount "26" @default.
• W2346779129 countsByYear W23467791292016 @default.
• W2346779129 countsByYear W23467791292017 @default.
• W2346779129 countsByYear W23467791292018 @default.
• W2346779129 countsByYear W23467791292019 @default.
• W2346779129 countsByYear W23467791292020 @default.
• W2346779129 countsByYear W23467791292021 @default.
• W2346779129 countsByYear W23467791292022 @default.
• W2346779129 countsByYear W23467791292023 @default.
• W2346779129 crossrefType "journal-article" @default.
• W2346779129 hasAuthorship W2346779129A5009608111 @default.
• W2346779129 hasAuthorship W2346779129A5068234373 @default.
• W2346779129 hasBestOaLocation W23467791291 @default.
• W2346779129 hasConcept C104317684 @default.
• W2346779129 hasConcept C121608353 @default.
• W2346779129 hasConcept C126322002 @default.
• W2346779129 hasConcept C143998085 @default.
• W2346779129 hasConcept C150194340 @default.
• W2346779129 hasConcept C190727270 @default.
• W2346779129 hasConcept C2781187634 @default.
• W2346779129 hasConcept C33288867 @default.
• W2346779129 hasConcept C502942594 @default.
• W2346779129 hasConcept C526805850 @default.
• W2346779129 hasConcept C54355233 @default.
• W2346779129 hasConcept C552990157 @default.
• W2346779129 hasConcept C60644358 @default.
• W2346779129 hasConcept C71924100 @default.
• W2346779129 hasConcept C86803240 @default.
• W2346779129 hasConceptScore W2346779129C104317684 @default.
• W2346779129 hasConceptScore W2346779129C121608353 @default.
• W2346779129 hasConceptScore W2346779129C126322002 @default.
• W2346779129 hasConceptScore W2346779129C143998085 @default.
• W2346779129 hasConceptScore W2346779129C150194340 @default.
• W2346779129 hasConceptScore W2346779129C190727270 @default.
• W2346779129 hasConceptScore W2346779129C2781187634 @default.
• W2346779129 hasConceptScore W2346779129C33288867 @default.
• W2346779129 hasConceptScore W2346779129C502942594 @default.
• W2346779129 hasConceptScore W2346779129C526805850 @default.
• W2346779129 hasConceptScore W2346779129C54355233 @default.
• W2346779129 hasConceptScore W2346779129C552990157 @default.
• W2346779129 hasConceptScore W2346779129C60644358 @default.
• W2346779129 hasConceptScore W2346779129C71924100 @default.
• W2346779129 hasConceptScore W2346779129C86803240 @default.
• W2346779129 hasIssue "35" @default.
• W2346779129 hasLocation W23467791291 @default.
• W2346779129 hasLocation W23467791292 @default.
• W2346779129 hasLocation W23467791293 @default.
• W2346779129 hasLocation W23467791294 @default.
• W2346779129 hasOpenAccess W2346779129 @default.
• W2346779129 hasPrimaryLocation W23467791291 @default.
• W2346779129 hasRelatedWork W1998770206 @default.
• W2346779129 hasRelatedWork W2049754458 @default.
• W2346779129 hasRelatedWork W2109712655 @default.
• W2346779129 hasRelatedWork W2350493697 @default.
• W2346779129 hasRelatedWork W2972416174 @default.

• next