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• W2346799963 abstract "Spiral ganglion neurons (SGNs) are usually damaged in sensorineural hearing loss. SGN-derived neural stem cells (NSCs) have been identified and proposed to differentiate into neurons to replace damaged SGNs. However, it remains obscure whether SGN-NSC-derived neurons (ScNs) are electrophysiologically functional and possess the capability to form neural connections. Here, we found that SGN-derived cells demonstrated NSC characteristics and differentiated into SGN-like glutamatergic neurons. Neurotrophins significantly increased neuronal differentiation and neurite length of ScNs. Patch clamp recording revealed that ScNs possessed SGN-like NaV and HCN channels, suggesting electrophysiological function. FM1-43 staining and synaptic protein immunofluorescence showed ScNs possess the ability to form neural connections. Astrocyte-conditioned medium was able to stimulate ScNs to express synaptic proteins. These data suggested that neurotrophins are able to stimulate postnatal SGN-NSCs to differentiate into functional glutamatergic ScNs with the capability to form synaptic connections in vitro." @default.
• W2346799963 created "2016-06-24" @default.
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• W2346799963 date "2016-05-15" @default.
• W2346799963 modified "2023-09-24" @default.
• W2346799963 title "Differentiation of Spiral Ganglion-Derived Neural Stem Cells into Functional Synaptogenetic Neurons" @default.
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• W2346799963 doi "https://doi.org/10.1089/scd.2015.0345" @default.
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