FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346808052> ?p ?o ?g. }

• W2346808052 endingPage "e0154963" @default.
• W2346808052 startingPage "e0154963" @default.
• W2346808052 abstract "Background and Objectives Hyperkalemia is a common electrolyte disorder that can result in fatal cardiac arrhythmias. Despite the importance of insulin as a lifesaving intervention in the treatment of hyperkalemia in an emergency setting, there is no consensus on the dose or the method (bolus or infusion) of its administration. Our aim was to review data in the literature to determine the optimal dose and route of administration of insulin in the management of emergency hyperkalemia. Design, Setting, Participants, & Measurements We searched several databases from their date of inception through February 2015 for eligible articles published in any language. We included any study that reported on the use of insulin in the management of hyperkalemia. Results We identified eleven studies. In seven studies, 10 units of regular insulin was administered (bolus in five studies, infusion in two studies), in one study 12 units of regular insulin was infused over 30 minutes, and in three studies 20 units of regular insulin was infused over 60 minutes. The majority of included studies were biased. There was no statistically significant difference in mean decrease in serum potassium (K+) concentration at 60 minutes between studies in which insulin was administered as an infusion of 20 units over 60 minutes and studies in which 10 units of insulin was administered as a bolus (0.79±0.25 mmol/L versus 0.78±0.25 mmol/L, P = 0.98) or studies in which 10 units of insulin was administered as an infusion (0.79±0.25 mmol/L versus 0.39±0.09 mmol/L, P = 0.1). Almost one fifth of the study population experienced an episode of hypoglycemia. Conclusion The limited data available in the literature shows no statistically significant difference between the different regimens of insulin used to acutely lower serum K+ concentration. Accordingly, 10 units of short acting insulin given intravenously may be used in cases of hyperkalemia. Alternatively, 20 units of short acting insulin may be given as a continuous intravenous infusion over 60 minutes in patients with severe hyperkalemia (i.e., serum K+ concentration > 6.5 mmol/L) and those with marked EKG changes related to hyperkalemia (e.g., prolonged PR interval, wide QRS complex) as an alternative to 10 units of short acting insulin. Because the risk of hypoglycemia is increased with using large insulin doses, sufficient glucose (60 grams with the administration of 20 units of insulin and 50 grams with the administration of 10 units) should be given to prevent hypoglycemia, and plasma glucose should be frequently monitored." @default.
• W2346808052 created "2016-06-24" @default.
• W2346808052 creator A5056937094 @default.
• W2346808052 creator A5067469887 @default.
• W2346808052 date "2016-05-05" @default.
• W2346808052 modified "2023-10-16" @default.
• W2346808052 title "Optimal Dose and Method of Administration of Intravenous Insulin in the Management of Emergency Hyperkalemia: A Systematic Review" @default.
• W2346808052 cites W1272035421 @default.
• W2346808052 cites W13059092 @default.
• W2346808052 cites W137466527 @default.
• W2346808052 cites W1848265894 @default.
• W2346808052 cites W1934946546 @default.
• W2346808052 cites W1979423827 @default.
• W2346808052 cites W1985173544 @default.
• W2346808052 cites W1996626805 @default.
• W2346808052 cites W2011978785 @default.
• W2346808052 cites W2030933332 @default.
• W2346808052 cites W2052349502 @default.
• W2346808052 cites W2086592442 @default.
• W2346808052 cites W2100817694 @default.
• W2346808052 cites W2119768791 @default.
• W2346808052 cites W2131066811 @default.
• W2346808052 cites W2132782035 @default.
• W2346808052 cites W2136761087 @default.
• W2346808052 cites W2142414962 @default.
• W2346808052 cites W2143189650 @default.
• W2346808052 cites W2143529132 @default.
• W2346808052 cites W2152512240 @default.
• W2346808052 cites W2154336683 @default.
• W2346808052 cites W2167774253 @default.
• W2346808052 cites W2170323379 @default.
• W2346808052 cites W2582602949 @default.
• W2346808052 cites W2588681363 @default.
• W2346808052 cites W190744277 @default.
• W2346808052 doi "https://doi.org/10.1371/journal.pone.0154963" @default.
• W2346808052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4857926" @default.
• W2346808052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27148740" @default.
• W2346808052 hasPublicationYear "2016" @default.
• W2346808052 type Work @default.
• W2346808052 sameAs 2346808052 @default.
• W2346808052 citedByCount "43" @default.
• W2346808052 countsByYear W23468080522017 @default.
• W2346808052 countsByYear W23468080522018 @default.
• W2346808052 countsByYear W23468080522019 @default.
• W2346808052 countsByYear W23468080522020 @default.
• W2346808052 countsByYear W23468080522021 @default.
• W2346808052 countsByYear W23468080522022 @default.
• W2346808052 countsByYear W23468080522023 @default.
• W2346808052 crossrefType "journal-article" @default.
• W2346808052 hasAuthorship W2346808052A5056937094 @default.
• W2346808052 hasAuthorship W2346808052A5067469887 @default.
• W2346808052 hasBestOaLocation W23468080521 @default.
• W2346808052 hasConcept C118552586 @default.
• W2346808052 hasConcept C126322002 @default.
• W2346808052 hasConcept C2779306644 @default.
• W2346808052 hasConcept C2779946736 @default.
• W2346808052 hasConcept C2780243291 @default.
• W2346808052 hasConcept C2780668416 @default.
• W2346808052 hasConcept C2780724011 @default.
• W2346808052 hasConcept C3020190219 @default.
• W2346808052 hasConcept C42219234 @default.
• W2346808052 hasConcept C43376680 @default.
• W2346808052 hasConcept C71924100 @default.
• W2346808052 hasConceptScore W2346808052C118552586 @default.
• W2346808052 hasConceptScore W2346808052C126322002 @default.
• W2346808052 hasConceptScore W2346808052C2779306644 @default.
• W2346808052 hasConceptScore W2346808052C2779946736 @default.
• W2346808052 hasConceptScore W2346808052C2780243291 @default.
• W2346808052 hasConceptScore W2346808052C2780668416 @default.
• W2346808052 hasConceptScore W2346808052C2780724011 @default.
• W2346808052 hasConceptScore W2346808052C3020190219 @default.
• W2346808052 hasConceptScore W2346808052C42219234 @default.
• W2346808052 hasConceptScore W2346808052C43376680 @default.
• W2346808052 hasConceptScore W2346808052C71924100 @default.
• W2346808052 hasIssue "5" @default.
• W2346808052 hasLocation W23468080521 @default.
• W2346808052 hasLocation W23468080522 @default.
• W2346808052 hasLocation W23468080523 @default.
• W2346808052 hasLocation W23468080524 @default.
• W2346808052 hasOpenAccess W2346808052 @default.
• W2346808052 hasPrimaryLocation W23468080521 @default.
• W2346808052 hasRelatedWork W1978287097 @default.
• W2346808052 hasRelatedWork W2011013009 @default.
• W2346808052 hasRelatedWork W2023856112 @default.
• W2346808052 hasRelatedWork W2032193446 @default.
• W2346808052 hasRelatedWork W2050749153 @default.
• W2346808052 hasRelatedWork W2083242203 @default.
• W2346808052 hasRelatedWork W2091079753 @default.
• W2346808052 hasRelatedWork W2129110422 @default.
• W2346808052 hasRelatedWork W2346808052 @default.
• W2346808052 hasRelatedWork W3029369316 @default.
• W2346808052 hasVolume "11" @default.
• W2346808052 isParatext "false" @default.
• W2346808052 isRetracted "false" @default.
• W2346808052 magId "2346808052" @default.
• W2346808052 workType "article" @default.