FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346862095> ?p ?o ?g. }

• W2346862095 endingPage "567" @default.
• W2346862095 startingPage "559" @default.
• W2346862095 abstract "Isolated luteal cells, prepared from superovulated rat ovaries by digestion with collagenase, were subjected to density-gradient centrifugation on Percoll to give a more highly purified preparation of luteal cells than has been reported previously. The cells formed progesterone when incubated in vitro; lutropin stimulated this steroidogenesis. Progesterone formation was linear for at least 2 h; a minimal lutropin concentration of 1.0 ng/ml was needed for stimulation and concentrations of 3.0 and 100 ng/ml gave half-maximal and maximal responses respectively. The cells were unresponsive towards hormones other than lutropin. Exposure to lutropin raised the cellular cyclic AMP concentration, and dibutyryl cyclic AMP, but not dibutyryl cyclic GMP, was as effective in stimulating steroidogenesis as was lutropin. Aminoglutethimide, an inhibitor of cholesterol side-chain cleavage, completely blocked progesterone formation by the cells, showing cholesterol side-chain cleavage to be an obligatory step in steroidogenesis by these cells. Neither the activity of 3-hydroxy-3-methylglutaryl-CoA reductase nor the incorporation of radioactively labelled acetate or mevalonate into cholesterol by cells incubated in vitro were detectable unless the rats had been treated previously with 4-aminopyrazolo[3,4-d]pyrimidine. In cells from rats so treated, compactin was found to block almost completely the incorporation of radioactively labelled acetate, but not of mevalonate, into cholesterol, indicating that this inhibitor acts in corpus luteum in the same way as it does in other tissues. In cells from rats not treated with 4-aminopyrazolo[3,4-d]pyrimidine compactin had no effect on progesterone formation in vitro, showing cholesterol biosynthesis to be unnecessary for the rapid steroidogenic response by luteal cells to lutropin." @default.
• W2346862095 created "2016-06-24" @default.
• W2346862095 creator A5015435376 @default.
• W2346862095 creator A5020670054 @default.
• W2346862095 creator A5085862674 @default.
• W2346862095 creator A5086391365 @default.
• W2346862095 date "1980-11-15" @default.
• W2346862095 modified "2023-09-27" @default.
• W2346862095 title "The preparation and purification of isolated rat corpus-luteum cells and their use in studying the relationship between cholesterol biosynthesis and the lutropin-stimulated formation of progesterone" @default.
• W2346862095 cites W1486963290 @default.
• W2346862095 cites W1539562977 @default.
• W2346862095 cites W1552809292 @default.
• W2346862095 cites W1603091820 @default.
• W2346862095 cites W184437021 @default.
• W2346862095 cites W18663656 @default.
• W2346862095 cites W1947355021 @default.
• W2346862095 cites W1966801188 @default.
• W2346862095 cites W1973055726 @default.
• W2346862095 cites W1973401515 @default.
• W2346862095 cites W1976615037 @default.
• W2346862095 cites W1977644047 @default.
• W2346862095 cites W1992737770 @default.
• W2346862095 cites W2001725885 @default.
• W2346862095 cites W2002267009 @default.
• W2346862095 cites W2012947562 @default.
• W2346862095 cites W2016496143 @default.
• W2346862095 cites W2025725001 @default.
• W2346862095 cites W2064576240 @default.
• W2346862095 cites W2078882071 @default.
• W2346862095 cites W2080888186 @default.
• W2346862095 cites W2156799866 @default.
• W2346862095 cites W2170850385 @default.
• W2346862095 cites W2313052492 @default.
• W2346862095 cites W2400351713 @default.
• W2346862095 cites W2415232886 @default.
• W2346862095 cites W2415333467 @default.
• W2346862095 cites W2419396513 @default.
• W2346862095 cites W2425357042 @default.
• W2346862095 cites W2464797585 @default.
• W2346862095 cites W93157018 @default.
• W2346862095 cites W1999494585 @default.
• W2346862095 doi "https://doi.org/10.1042/bj1920559" @default.
• W2346862095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1162371" @default.
• W2346862095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7236225" @default.
• W2346862095 hasPublicationYear "1980" @default.
• W2346862095 type Work @default.
• W2346862095 sameAs 2346862095 @default.
• W2346862095 citedByCount "29" @default.
• W2346862095 crossrefType "journal-article" @default.
• W2346862095 hasAuthorship W2346862095A5015435376 @default.
• W2346862095 hasAuthorship W2346862095A5020670054 @default.
• W2346862095 hasAuthorship W2346862095A5085862674 @default.
• W2346862095 hasAuthorship W2346862095A5086391365 @default.
• W2346862095 hasBestOaLocation W23468620952 @default.
• W2346862095 hasConcept C121608353 @default.
• W2346862095 hasConcept C126322002 @default.
• W2346862095 hasConcept C134018914 @default.
• W2346862095 hasConcept C143228043 @default.
• W2346862095 hasConcept C181199279 @default.
• W2346862095 hasConcept C185592680 @default.
• W2346862095 hasConcept C202751555 @default.
• W2346862095 hasConcept C24998067 @default.
• W2346862095 hasConcept C2775976807 @default.
• W2346862095 hasConcept C2776166826 @default.
• W2346862095 hasConcept C2776608385 @default.
• W2346862095 hasConcept C2778163477 @default.
• W2346862095 hasConcept C2778394429 @default.
• W2346862095 hasConcept C48679268 @default.
• W2346862095 hasConcept C526171541 @default.
• W2346862095 hasConcept C530470458 @default.
• W2346862095 hasConcept C55493867 @default.
• W2346862095 hasConcept C62231903 @default.
• W2346862095 hasConcept C71315377 @default.
• W2346862095 hasConcept C71924100 @default.
• W2346862095 hasConcept C80446465 @default.
• W2346862095 hasConcept C86803240 @default.
• W2346862095 hasConceptScore W2346862095C121608353 @default.
• W2346862095 hasConceptScore W2346862095C126322002 @default.
• W2346862095 hasConceptScore W2346862095C134018914 @default.
• W2346862095 hasConceptScore W2346862095C143228043 @default.
• W2346862095 hasConceptScore W2346862095C181199279 @default.
• W2346862095 hasConceptScore W2346862095C185592680 @default.
• W2346862095 hasConceptScore W2346862095C202751555 @default.
• W2346862095 hasConceptScore W2346862095C24998067 @default.
• W2346862095 hasConceptScore W2346862095C2775976807 @default.
• W2346862095 hasConceptScore W2346862095C2776166826 @default.
• W2346862095 hasConceptScore W2346862095C2776608385 @default.
• W2346862095 hasConceptScore W2346862095C2778163477 @default.
• W2346862095 hasConceptScore W2346862095C2778394429 @default.
• W2346862095 hasConceptScore W2346862095C48679268 @default.
• W2346862095 hasConceptScore W2346862095C526171541 @default.
• W2346862095 hasConceptScore W2346862095C530470458 @default.
• W2346862095 hasConceptScore W2346862095C55493867 @default.
• W2346862095 hasConceptScore W2346862095C62231903 @default.
• W2346862095 hasConceptScore W2346862095C71315377 @default.
• W2346862095 hasConceptScore W2346862095C71924100 @default.
• W2346862095 hasConceptScore W2346862095C80446465 @default.
• W2346862095 hasConceptScore W2346862095C86803240 @default.

• next