FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346877203> ?p ?o ?g. }

• W2346877203 abstract "Abstract Highly diverse phenotypic traits are often encoded by clusters of gene paralogs that are physically linked on chromosomes. Examples include olfactory receptor gene clusters involved in the recognition of diverse odors, defensin and phospholipase gene clusters involved in snake venoms, and Hox gene clusters involved in morphological diversity. Historically, gene clusters have been identified subjectively as genomic neighborhoods containing several paralogs, however, their genomic arrangements are often highly variable with respect to gene number, intergenic distance, and synteny. For example, the prolactin gene cluster shows variation in paralogous gene number, order and intergenic distance across mammals, whereas animal Hox gene clusters are often broken into sub-clusters of different sizes. A lack of formal definition for clusters of gene paralogs does not only hamper the study of their evolutionary dynamics, but also the discovery of novel ones in the exponentially growing body of genomic data. To address this gap, we developed a novel homology-based algorithm, CGPFinder, which formalizes and automates the identification of clusters of gene paralogs (CGPs) by examining the physical distribution of individual gene members of families of paralogous genes across chromosomes. Application of CGPFinder to diverse mammalian genomes accurately identified CGPs for many well-known gene clusters in the human and mouse genomes (e.g., Hox, protocadherin, Siglec, and beta-globin gene clusters) as well as for 20 other mammalian genomes. Differences were due to the exclusion of non-homologous genes that have historically been considered parts of specific gene clusters, the inclusion or absence of one or more genes between the CGPs and their corresponding gene clusters, and the splitting of certain gene clusters into distinct CGPs. Finally, examination of human genes showing tissue-specific enhancement of their expression by CGPFinder identified members of several well-known gene clusters (e.g., cytochrome P450, aquaporins, and olfactory receptors) and revealed that they were unequally distributed across tissues. By formalizing and automating the identification of CGPs and of genes that are members of CGPs, CGPFinder will facilitate furthering our understanding of the evolutionary dynamics of genomic neighborhoods containing CGPs, their functional implications, and how they are associated with phenotypic diversity." @default.
• W2346877203 created "2016-06-24" @default.
• W2346877203 creator A5046883178 @default.
• W2346877203 creator A5059582484 @default.
• W2346877203 date "2016-05-05" @default.
• W2346877203 modified "2023-10-16" @default.
• W2346877203 title "A novel homology-based algorithm for the identification of physically linked clusters of paralogous genes" @default.
• W2346877203 cites W1483189080 @default.
• W2346877203 cites W1540381414 @default.
• W2346877203 cites W1599391997 @default.
• W2346877203 cites W1965178844 @default.
• W2346877203 cites W1971231926 @default.
• W2346877203 cites W1973072452 @default.
• W2346877203 cites W1981868769 @default.
• W2346877203 cites W1985348819 @default.
• W2346877203 cites W1989811792 @default.
• W2346877203 cites W1990061796 @default.
• W2346877203 cites W2000162659 @default.
• W2346877203 cites W2003917529 @default.
• W2346877203 cites W2010034236 @default.
• W2346877203 cites W2012034410 @default.
• W2346877203 cites W2017639899 @default.
• W2346877203 cites W2020869819 @default.
• W2346877203 cites W2028983214 @default.
• W2346877203 cites W2032223502 @default.
• W2346877203 cites W2045426130 @default.
• W2346877203 cites W2048249977 @default.
• W2346877203 cites W2052923559 @default.
• W2346877203 cites W2062457563 @default.
• W2346877203 cites W2062954665 @default.
• W2346877203 cites W2063759364 @default.
• W2346877203 cites W2067180080 @default.
• W2346877203 cites W2069638671 @default.
• W2346877203 cites W2077309447 @default.
• W2346877203 cites W2084805548 @default.
• W2346877203 cites W2090027454 @default.
• W2346877203 cites W2099049981 @default.
• W2346877203 cites W2099245827 @default.
• W2346877203 cites W2105007587 @default.
• W2346877203 cites W2107449113 @default.
• W2346877203 cites W2113129387 @default.
• W2346877203 cites W2113440413 @default.
• W2346877203 cites W2118881803 @default.
• W2346877203 cites W2120033918 @default.
• W2346877203 cites W2121886007 @default.
• W2346877203 cites W2123683847 @default.
• W2346877203 cites W2130233997 @default.
• W2346877203 cites W2130988208 @default.
• W2346877203 cites W2133831816 @default.
• W2346877203 cites W2135271831 @default.
• W2346877203 cites W2135409136 @default.
• W2346877203 cites W2139134537 @default.
• W2346877203 cites W2146264881 @default.
• W2346877203 cites W2147912202 @default.
• W2346877203 cites W2150012832 @default.
• W2346877203 cites W2150146437 @default.
• W2346877203 cites W2159459394 @default.
• W2346877203 cites W2161854299 @default.
• W2346877203 cites W2168696662 @default.
• W2346877203 cites W2169550012 @default.
• W2346877203 cites W225724404 @default.
• W2346877203 cites W4236236547 @default.
• W2346877203 cites W4294117523 @default.
• W2346877203 cites W4297845870 @default.
• W2346877203 cites W942832854 @default.
• W2346877203 doi "https://doi.org/10.1101/051953" @default.
• W2346877203 hasPublicationYear "2016" @default.
• W2346877203 type Work @default.
• W2346877203 sameAs 2346877203 @default.
• W2346877203 citedByCount "0" @default.
• W2346877203 crossrefType "posted-content" @default.
• W2346877203 hasAuthorship W2346877203A5046883178 @default.
• W2346877203 hasAuthorship W2346877203A5059582484 @default.
• W2346877203 hasBestOaLocation W23468772031 @default.
• W2346877203 hasConcept C104317684 @default.
• W2346877203 hasConcept C111039654 @default.
• W2346877203 hasConcept C141231307 @default.
• W2346877203 hasConcept C150194340 @default.
• W2346877203 hasConcept C165525559 @default.
• W2346877203 hasConcept C36857842 @default.
• W2346877203 hasConcept C53702515 @default.
• W2346877203 hasConcept C54355233 @default.
• W2346877203 hasConcept C5911399 @default.
• W2346877203 hasConcept C70721500 @default.
• W2346877203 hasConcept C78458016 @default.
• W2346877203 hasConcept C86803240 @default.
• W2346877203 hasConceptScore W2346877203C104317684 @default.
• W2346877203 hasConceptScore W2346877203C111039654 @default.
• W2346877203 hasConceptScore W2346877203C141231307 @default.
• W2346877203 hasConceptScore W2346877203C150194340 @default.
• W2346877203 hasConceptScore W2346877203C165525559 @default.
• W2346877203 hasConceptScore W2346877203C36857842 @default.
• W2346877203 hasConceptScore W2346877203C53702515 @default.
• W2346877203 hasConceptScore W2346877203C54355233 @default.
• W2346877203 hasConceptScore W2346877203C5911399 @default.
• W2346877203 hasConceptScore W2346877203C70721500 @default.
• W2346877203 hasConceptScore W2346877203C78458016 @default.
• W2346877203 hasConceptScore W2346877203C86803240 @default.
• W2346877203 hasLocation W23468772031 @default.
• W2346877203 hasLocation W23468772032 @default.

• next