FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346947770> ?p ?o ?g. }

• W2346947770 endingPage "64" @default.
• W2346947770 startingPage "64" @default.
• W2346947770 abstract "It is supposed that human colorectal cancer consists of a phenotypically distinct population of tumorigenic cancer cells known as cancer stem cells (CSCs) which play a pivotal role in cancer progression, maintenance, metastasis, and the relapse. The aim of this effort was to investigate and compare biological characterizations of CD133+ with CD133- cell subsets isolated from both primary and metastatic human colorectal tumors.Using our optimized protocols, unfixed colorectal tumors were enzymatically and mechanically dissociated into single cells followed by evaluation of postdigestion viability. The obtained single cell suspensions were then subjected to cell sorting using magnetic beads according to CD133 marker. The resultant CD133+ and CD133- cell subsets were cultured in specific cell culture medium followed by aldehyde dehydrogenases (ALDH) activity assessment and flow cytometric analyses.The results demonstrate that CD133+ cells have smaller size and lower complexity of intracellular structure, sphere formation ability, and ALDH enzyme activity while CD133- cells isolated from primary colon cancer samples were not able to form a sphere and did not show ALDH enzyme activity. Intriguingly, CD133- cells isolated from metastatic colorectal cancer specimen were able to form a sphere and shown ALDH enzyme activity. The present study indicates that our results are in agreement with SC theory and possibility of the existence of cellular plasticity among cancer subpopulations should be portrayed.We also conclude that this cellular plasticity is greatly affected by tumor microenvironment cues and the role of CSCs niche in cancer therapeutic strategies should be precisely considered." @default.
• W2346947770 created "2016-06-24" @default.
• W2346947770 creator A5014784394 @default.
• W2346947770 creator A5016688025 @default.
• W2346947770 creator A5031560022 @default.
• W2346947770 creator A5048139853 @default.
• W2346947770 creator A5048826303 @default.
• W2346947770 creator A5058516379 @default.
• W2346947770 creator A5059447343 @default.
• W2346947770 creator A5071764880 @default.
• W2346947770 date "2016-01-01" @default.
• W2346947770 modified "2023-09-30" @default.
• W2346947770 title "Deciphering biological characteristics of tumorigenic subpopulations in human colorectal cancer reveals cellular plasticity" @default.
• W2346947770 cites W1530682031 @default.
• W2346947770 cites W1968541478 @default.
• W2346947770 cites W1983357205 @default.
• W2346947770 cites W2001258296 @default.
• W2346947770 cites W2001544973 @default.
• W2346947770 cites W2001765718 @default.
• W2346947770 cites W2003727125 @default.
• W2346947770 cites W2009886857 @default.
• W2346947770 cites W2019264784 @default.
• W2346947770 cites W2023427658 @default.
• W2346947770 cites W2028663226 @default.
• W2346947770 cites W2028980412 @default.
• W2346947770 cites W2029231546 @default.
• W2346947770 cites W2033726327 @default.
• W2346947770 cites W2038873665 @default.
• W2346947770 cites W2041491387 @default.
• W2346947770 cites W2050300062 @default.
• W2346947770 cites W2051055358 @default.
• W2346947770 cites W2052530372 @default.
• W2346947770 cites W2058400226 @default.
• W2346947770 cites W2058763255 @default.
• W2346947770 cites W2096744745 @default.
• W2346947770 cites W2099090234 @default.
• W2346947770 cites W2102085111 @default.
• W2346947770 cites W2103075972 @default.
• W2346947770 cites W2106584923 @default.
• W2346947770 cites W2106787323 @default.
• W2346947770 cites W2129375080 @default.
• W2346947770 cites W2144408907 @default.
• W2346947770 cites W2156149964 @default.
• W2346947770 cites W2156365913 @default.
• W2346947770 cites W2158049101 @default.
• W2346947770 cites W2160732073 @default.
• W2346947770 cites W2171974881 @default.
• W2346947770 doi "https://doi.org/10.4103/1735-1995.187355" @default.
• W2346947770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5122187" @default.
• W2346947770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27904609" @default.
• W2346947770 hasPublicationYear "2016" @default.
• W2346947770 type Work @default.
• W2346947770 sameAs 2346947770 @default.
• W2346947770 citedByCount "24" @default.
• W2346947770 countsByYear W23469477702016 @default.
• W2346947770 countsByYear W23469477702017 @default.
• W2346947770 countsByYear W23469477702018 @default.
• W2346947770 countsByYear W23469477702019 @default.
• W2346947770 countsByYear W23469477702020 @default.
• W2346947770 countsByYear W23469477702023 @default.
• W2346947770 crossrefType "journal-article" @default.
• W2346947770 hasAuthorship W2346947770A5014784394 @default.
• W2346947770 hasAuthorship W2346947770A5016688025 @default.
• W2346947770 hasAuthorship W2346947770A5031560022 @default.
• W2346947770 hasAuthorship W2346947770A5048139853 @default.
• W2346947770 hasAuthorship W2346947770A5048826303 @default.
• W2346947770 hasAuthorship W2346947770A5058516379 @default.
• W2346947770 hasAuthorship W2346947770A5059447343 @default.
• W2346947770 hasAuthorship W2346947770A5071764880 @default.
• W2346947770 hasBestOaLocation W23469477701 @default.
• W2346947770 hasConcept C121608353 @default.
• W2346947770 hasConcept C142724271 @default.
• W2346947770 hasConcept C1491633281 @default.
• W2346947770 hasConcept C181199279 @default.
• W2346947770 hasConcept C25747580 @default.
• W2346947770 hasConcept C2779013556 @default.
• W2346947770 hasConcept C28328180 @default.
• W2346947770 hasConcept C2908647359 @default.
• W2346947770 hasConcept C502942594 @default.
• W2346947770 hasConcept C526805850 @default.
• W2346947770 hasConcept C54355233 @default.
• W2346947770 hasConcept C55427017 @default.
• W2346947770 hasConcept C55493867 @default.
• W2346947770 hasConcept C71924100 @default.
• W2346947770 hasConcept C86803240 @default.
• W2346947770 hasConcept C95444343 @default.
• W2346947770 hasConcept C96232424 @default.
• W2346947770 hasConcept C99454951 @default.
• W2346947770 hasConceptScore W2346947770C121608353 @default.
• W2346947770 hasConceptScore W2346947770C142724271 @default.
• W2346947770 hasConceptScore W2346947770C1491633281 @default.
• W2346947770 hasConceptScore W2346947770C181199279 @default.
• W2346947770 hasConceptScore W2346947770C25747580 @default.
• W2346947770 hasConceptScore W2346947770C2779013556 @default.
• W2346947770 hasConceptScore W2346947770C28328180 @default.
• W2346947770 hasConceptScore W2346947770C2908647359 @default.
• W2346947770 hasConceptScore W2346947770C502942594 @default.
• W2346947770 hasConceptScore W2346947770C526805850 @default.

• next