Matches in SemOpenAlex for { <https://semopenalex.org/work/W2346996915> ?p ?o ?g. }
- W2346996915 endingPage "41" @default.
- W2346996915 startingPage "32" @default.
- W2346996915 abstract "Triflumezopyrim, a newly commercialized molecule from DuPont Crop Protection, belongs to the novel class of mesoionic insecticides. This study characterizes the biochemical and physiological action of this novel insecticide. Using membranes from the aphid, Myzus persicae, triflumezopyrim was found to displace 3H-imidacloprid with a Ki value of 43 nM with competitive binding results indicating that triflumezopyrim binds to the orthosteric site of the nicotinic acetylcholine receptor (nAChR). In voltage clamp studies using dissociated Periplaneta americana neurons, triflumezopyrim inhibits nAChR currents with an IC50 of 0.6 nM. Activation of nAChR currents was minimal and required concentrations ≥100 μM. Xenopus oocytes expressing chimeric nAChRs (Drosophila α2/chick β2) showed similar inhibitory effects from triflumezopyrim. In P. americana neurons, co-application experiments with acetylcholine reveal the inhibitory action of triflumezopyrim to be rapid and prolonged in nature. Such physiological action is distinct from other insecticides in IRAC Group 4 in which the toxicological mode of action is attributed to nAChR agonism. Mesoionic insecticides act via inhibition of the orthosteric binding site of the nAChR despite previous beliefs that such action would translate to poor insect control. Triflumezopyrim is the first commercialized insecticide from this class and provides outstanding control of hoppers, including the brown planthopper, Nilaparvata lugens, which is already displaying strong resistance to neonicotinoids such as imidacloprid." @default.
- W2346996915 created "2016-06-24" @default.
- W2346996915 creator A5006914569 @default.
- W2346996915 creator A5010770362 @default.
- W2346996915 creator A5024251017 @default.
- W2346996915 creator A5036280484 @default.
- W2346996915 creator A5056971062 @default.
- W2346996915 creator A5073704240 @default.
- W2346996915 creator A5079493144 @default.
- W2346996915 creator A5087363157 @default.
- W2346996915 creator A5090234797 @default.
- W2346996915 date "2016-07-01" @default.
- W2346996915 modified "2023-10-02" @default.
- W2346996915 title "Mode of action of triflumezopyrim: A novel mesoionic insecticide which inhibits the nicotinic acetylcholine receptor" @default.
- W2346996915 cites W1511989025 @default.
- W2346996915 cites W1564990428 @default.
- W2346996915 cites W1646134431 @default.
- W2346996915 cites W1964662732 @default.
- W2346996915 cites W1971021330 @default.
- W2346996915 cites W1981141689 @default.
- W2346996915 cites W1984147326 @default.
- W2346996915 cites W1988320485 @default.
- W2346996915 cites W1990564020 @default.
- W2346996915 cites W2003203798 @default.
- W2346996915 cites W2014738171 @default.
- W2346996915 cites W2016476464 @default.
- W2346996915 cites W2016761469 @default.
- W2346996915 cites W2021814361 @default.
- W2346996915 cites W2024445699 @default.
- W2346996915 cites W2026006839 @default.
- W2346996915 cites W2029155536 @default.
- W2346996915 cites W2030460402 @default.
- W2346996915 cites W2032733808 @default.
- W2346996915 cites W2037577782 @default.
- W2346996915 cites W2039253331 @default.
- W2346996915 cites W2044849212 @default.
- W2346996915 cites W2046797657 @default.
- W2346996915 cites W2055333952 @default.
- W2346996915 cites W2058427270 @default.
- W2346996915 cites W2060069328 @default.
- W2346996915 cites W2061475648 @default.
- W2346996915 cites W2072585899 @default.
- W2346996915 cites W2080578347 @default.
- W2346996915 cites W2081053713 @default.
- W2346996915 cites W2084912505 @default.
- W2346996915 cites W2093912953 @default.
- W2346996915 cites W2111627512 @default.
- W2346996915 cites W2123847061 @default.
- W2346996915 cites W2153695039 @default.
- W2346996915 cites W2316745573 @default.
- W2346996915 cites W2404184727 @default.
- W2346996915 doi "https://doi.org/10.1016/j.ibmb.2016.04.008" @default.
- W2346996915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27130855" @default.
- W2346996915 hasPublicationYear "2016" @default.
- W2346996915 type Work @default.
- W2346996915 sameAs 2346996915 @default.
- W2346996915 citedByCount "81" @default.
- W2346996915 countsByYear W23469969152016 @default.
- W2346996915 countsByYear W23469969152017 @default.
- W2346996915 countsByYear W23469969152018 @default.
- W2346996915 countsByYear W23469969152019 @default.
- W2346996915 countsByYear W23469969152020 @default.
- W2346996915 countsByYear W23469969152021 @default.
- W2346996915 countsByYear W23469969152022 @default.
- W2346996915 countsByYear W23469969152023 @default.
- W2346996915 crossrefType "journal-article" @default.
- W2346996915 hasAuthorship W2346996915A5006914569 @default.
- W2346996915 hasAuthorship W2346996915A5010770362 @default.
- W2346996915 hasAuthorship W2346996915A5024251017 @default.
- W2346996915 hasAuthorship W2346996915A5036280484 @default.
- W2346996915 hasAuthorship W2346996915A5056971062 @default.
- W2346996915 hasAuthorship W2346996915A5073704240 @default.
- W2346996915 hasAuthorship W2346996915A5079493144 @default.
- W2346996915 hasAuthorship W2346996915A5087363157 @default.
- W2346996915 hasAuthorship W2346996915A5090234797 @default.
- W2346996915 hasConcept C121587506 @default.
- W2346996915 hasConcept C12554922 @default.
- W2346996915 hasConcept C155647269 @default.
- W2346996915 hasConcept C161176658 @default.
- W2346996915 hasConcept C169760540 @default.
- W2346996915 hasConcept C170493617 @default.
- W2346996915 hasConcept C17077164 @default.
- W2346996915 hasConcept C185592680 @default.
- W2346996915 hasConcept C188987157 @default.
- W2346996915 hasConcept C18903297 @default.
- W2346996915 hasConcept C2775910092 @default.
- W2346996915 hasConcept C2776784398 @default.
- W2346996915 hasConcept C2777346155 @default.
- W2346996915 hasConcept C2777500947 @default.
- W2346996915 hasConcept C2779570518 @default.
- W2346996915 hasConcept C2780569236 @default.
- W2346996915 hasConcept C2780625307 @default.
- W2346996915 hasConcept C2909754679 @default.
- W2346996915 hasConcept C55493867 @default.
- W2346996915 hasConcept C6557445 @default.
- W2346996915 hasConcept C80161118 @default.
- W2346996915 hasConcept C86803240 @default.
- W2346996915 hasConcept C98274493 @default.