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- W2347029227 endingPage "15" @default.
- W2347029227 startingPage "3" @default.
- W2347029227 abstract "Pterygium is a common ophthalmic disease affecting humans only. Extensive epidemiological data have demonstrated a causative effect of chronic ultraviolet (UV) radiation on pterygia. Progress has been made in determining the origin of pterygia, their nasal predilection and wing‑shaped appearance, and the roles of UV radiation in the initiation and the development of pterygia. In the present review, the current understanding of the involvement of UV radiation in the pathogenesis of pterygia is summarized. This involvement includes the alteration of limbal stem cells and fibroblasts that contribute to the initiation of pterygia and the induction of various pro‑inflammatory cytokines, growth factors and matrix metalloproteinases that promote the progression of pterygia. Further elucidation of the roles of UV radiation in the pathogenesis of pterygia may help to encourage individuals at risk of developing pterygia to take preventive measures and aid researchers in the development of novel targeted therapeutic agents to treat pterygia." @default.
- W2347029227 created "2016-06-24" @default.
- W2347029227 creator A5018568072 @default.
- W2347029227 creator A5026590565 @default.
- W2347029227 creator A5054907664 @default.
- W2347029227 creator A5080256378 @default.
- W2347029227 creator A5084803967 @default.
- W2347029227 date "2016-05-09" @default.
- W2347029227 modified "2023-10-10" @default.
- W2347029227 title "The role of ultraviolet radiation in the pathogenesis of pterygia (Review)" @default.
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