Matches in SemOpenAlex for { <https://semopenalex.org/work/W2347031432> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2347031432 abstract "Glycyl-tRNA synthetase (GlyRS) is one of the key enzymes involved in protein synthesis. Its mutations have been reported to cause Charcot-Marie-Tooth disease which demonstrates muscular atrophy in distal extremities, particularly manifested in peroneus muscles. In this situation, the dysfunctions of mitochondria and sarcoplasmic reticulum (SR) affect energy supply and excitation-contraction coupling of muscle fibers, therefore resulting in muscular atrophy. Although the treatment of muscular atrophy is a global urgent problem, it can be improved by electroacupuncture (EA) treatment. To investigate the mechanism underlying EA treatment improving muscular atrophy, we focused on the perspective of protein synthesis by establishing a penicillin injection-induced sciatic nerve injury model. In our model, injured rats without treatment showed decreased sciatic functional index (SFI), decreased peroneus longus muscle weight and muscle fiber cross-sectional area, aggregated mitochondria with vacuoles appearing, swollen SR, and downregulated mRNA and protein expression levels of GlyRS and myosin heavy chain IIb (MHC-IIb). The injured rats with EA treatment showed significant recovery. These results indicated that EA stimulation can alleviate peroneus longus muscular atrophy induced by iatrogenic sciatic nerve injury through promoting the recovery of GlyRS and muscle ultrastructure and increasing muscle protein synthesis." @default.
- W2347031432 created "2016-06-24" @default.
- W2347031432 creator A5015896077 @default.
- W2347031432 creator A5074367524 @default.
- W2347031432 creator A5081734248 @default.
- W2347031432 date "2016-01-01" @default.
- W2347031432 modified "2023-10-16" @default.
- W2347031432 title "Effect of Electroacupuncture on the Expression of Glycyl-tRNA Synthetase and Ultrastructure Changes in Atrophied Rat Peroneus Longus Muscle Induced by Sciatic Nerve Injection Injury" @default.
- W2347031432 cites W1530473805 @default.
- W2347031432 cites W1531080825 @default.
- W2347031432 cites W1841023972 @default.
- W2347031432 cites W1971593246 @default.
- W2347031432 cites W1985534077 @default.
- W2347031432 cites W1991530982 @default.
- W2347031432 cites W2010199560 @default.
- W2347031432 cites W2023797948 @default.
- W2347031432 cites W2031182153 @default.
- W2347031432 cites W2035616056 @default.
- W2347031432 cites W2038999596 @default.
- W2347031432 cites W2040262845 @default.
- W2347031432 cites W2047799186 @default.
- W2347031432 cites W2050092365 @default.
- W2347031432 cites W2058565851 @default.
- W2347031432 cites W2060841020 @default.
- W2347031432 cites W2084034472 @default.
- W2347031432 cites W2110089867 @default.
- W2347031432 cites W2131313048 @default.
- W2347031432 cites W2133017629 @default.
- W2347031432 cites W2134040122 @default.
- W2347031432 cites W2155064170 @default.
- W2347031432 cites W2157644555 @default.
- W2347031432 cites W2181472284 @default.
- W2347031432 cites W2209590166 @default.
- W2347031432 cites W2267378516 @default.
- W2347031432 cites W2389228070 @default.
- W2347031432 cites W2414291493 @default.
- W2347031432 doi "https://doi.org/10.1155/2016/7536234" @default.
- W2347031432 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4870356" @default.
- W2347031432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27274754" @default.
- W2347031432 hasPublicationYear "2016" @default.
- W2347031432 type Work @default.
- W2347031432 sameAs 2347031432 @default.
- W2347031432 citedByCount "2" @default.
- W2347031432 countsByYear W23470314322017 @default.
- W2347031432 countsByYear W23470314322019 @default.
- W2347031432 crossrefType "journal-article" @default.
- W2347031432 hasAuthorship W2347031432A5015896077 @default.
- W2347031432 hasAuthorship W2347031432A5074367524 @default.
- W2347031432 hasAuthorship W2347031432A5081734248 @default.
- W2347031432 hasBestOaLocation W23470314321 @default.
- W2347031432 hasConcept C105702510 @default.
- W2347031432 hasConcept C126322002 @default.
- W2347031432 hasConcept C134018914 @default.
- W2347031432 hasConcept C2776263037 @default.
- W2347031432 hasConcept C2778369016 @default.
- W2347031432 hasConcept C2779732806 @default.
- W2347031432 hasConcept C2779959927 @default.
- W2347031432 hasConcept C2780105995 @default.
- W2347031432 hasConcept C2781149210 @default.
- W2347031432 hasConcept C2781172350 @default.
- W2347031432 hasConcept C6997183 @default.
- W2347031432 hasConcept C71924100 @default.
- W2347031432 hasConcept C86803240 @default.
- W2347031432 hasConcept C95444343 @default.
- W2347031432 hasConceptScore W2347031432C105702510 @default.
- W2347031432 hasConceptScore W2347031432C126322002 @default.
- W2347031432 hasConceptScore W2347031432C134018914 @default.
- W2347031432 hasConceptScore W2347031432C2776263037 @default.
- W2347031432 hasConceptScore W2347031432C2778369016 @default.
- W2347031432 hasConceptScore W2347031432C2779732806 @default.
- W2347031432 hasConceptScore W2347031432C2779959927 @default.
- W2347031432 hasConceptScore W2347031432C2780105995 @default.
- W2347031432 hasConceptScore W2347031432C2781149210 @default.
- W2347031432 hasConceptScore W2347031432C2781172350 @default.
- W2347031432 hasConceptScore W2347031432C6997183 @default.
- W2347031432 hasConceptScore W2347031432C71924100 @default.
- W2347031432 hasConceptScore W2347031432C86803240 @default.
- W2347031432 hasConceptScore W2347031432C95444343 @default.
- W2347031432 hasLocation W23470314321 @default.
- W2347031432 hasLocation W23470314322 @default.
- W2347031432 hasLocation W23470314323 @default.
- W2347031432 hasLocation W23470314324 @default.
- W2347031432 hasLocation W23470314325 @default.
- W2347031432 hasOpenAccess W2347031432 @default.
- W2347031432 hasPrimaryLocation W23470314321 @default.
- W2347031432 hasRelatedWork W1992604738 @default.
- W2347031432 hasRelatedWork W1998156341 @default.
- W2347031432 hasRelatedWork W2007808860 @default.
- W2347031432 hasRelatedWork W2089292912 @default.
- W2347031432 hasRelatedWork W2127318580 @default.
- W2347031432 hasRelatedWork W2339029146 @default.
- W2347031432 hasRelatedWork W2347031432 @default.
- W2347031432 hasRelatedWork W2373399179 @default.
- W2347031432 hasRelatedWork W2378920557 @default.
- W2347031432 hasRelatedWork W3210939416 @default.
- W2347031432 isParatext "false" @default.
- W2347031432 isRetracted "false" @default.
- W2347031432 magId "2347031432" @default.
- W2347031432 workType "article" @default.