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• W2347038782 startingPage "399" @default.
• W2347038782 abstract "In the present study, a series of 2,4-diarylpyrano[3,2-c]chromen-5(4H)-ones were synthesised and evaluated as antiproliferative agents. The compounds were evaluated against a panel of human cancer cell lines. CH-1 exhibited significant cytoxicity against HCT 116 cell lines with an IC50 value of 1.4 and 4.3 µM against MiaPaCa-2 cell lines. The compound CH-1 was found to induce apoptosis as evidenced by phase contrast microscopy, Hoechst 33258 staining and mitochondrial membrane potential (MMP) loss. The cell phase distribution studies indicated that the apoptotic population increased from 10.22% in the control sample to 57.19% in a sample treated with 20 µM compound CH-1." @default.
• W2347038782 created "2016-06-24" @default.
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• W2347038782 date "2016-01-01" @default.
• W2347038782 modified "2023-10-16" @default.
• W2347038782 title "2,4-Diarylpyrano[3,2-<i>c</i>]chromen-5(4<i>H</i>)-ones as Antiproliferative Agents:" @default.
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• W2347038782 doi "https://doi.org/10.1248/cpb.c15-00958" @default.
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