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- W2347169366 endingPage "502" @default.
- W2347169366 startingPage "485" @default.
- W2347169366 abstract "It has been 20 years since it was first postulated that developing T-cells undergo a positive selection process that ensures that only those bearing self-MHC restricted TCRαβ mature and exit the thymus to form the peripheral T-cell pool (1,2). It is now clear that positive selection operates on a pool of immature TCRαβ+ thymocytes that express high levels of CD4 and CD8. These coreceptors recognize MHC Class II or Class I molecules, respectively, and function both to stabilize TCRαβ interactions with MHC/peptide ligands, as well to recruit the Lck protein tyrosine kinase to the TCRαβ/CD3 complex, thus facilitating TCR-mediated signal transduction. In response to low avidity interactions between TCRαβ and MHC/peptide ligands expressed in the thymic cortex, DP thymocytes bearing potentially useful, self MHC-restricted TCRαβ are positively selected to survive and to mature into MHC II-restricted CD4+ helper, or MHC I-restricted CD8+ cytotoxic T-cells. Thus, positively selected DP thymocytes are rescued from programmed cell death, the fate of most DP cells, and become committed to the CD4 or CD8 single positive (SP) lineage. However, high avidity TCR-ligand interactions preferentially mediate clonal deletion of potentially autoreactive precursors, usually before the DP→SP transition is complete." @default.
- W2347169366 created "2016-06-24" @default.
- W2347169366 creator A5080038046 @default.
- W2347169366 date "1998-01-01" @default.
- W2347169366 modified "2023-10-14" @default.
- W2347169366 title "The Molecular Basis of Thymocyte Positive Selection and CD4/CD8 Lineage Commitment" @default.
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