Matches in SemOpenAlex for { <https://semopenalex.org/work/W2347177733> ?p ?o ?g. }
- W2347177733 endingPage "179" @default.
- W2347177733 startingPage "151" @default.
- W2347177733 abstract "Glycosylated antitumor ether lipids (GAELs) are a class of synthetic antitumor ether lipids (AELs) with a sugar moiety in place of the phosphocholine found in the prototypical AEL, edelfosine. This chapter reviews the development of GAELs as antitumor agents. Studies on structure–activity relationships, mechanism of induction of cell death, metabolism, selectivity against cancer cells, toxicity, hemolysis and thrombogenic effects are discussed. The requirements for significant cytotoxic activity include a glycerol moiety, a cationic sugar other than mannose and an O- or C-glycosidic bond with either α- or β-configuration. Compounds with S- and N-glycosidic linkages are not very active. The most active GAEL to date, 1-O-hexadecyl-2-O-methyl-3-O-(2′-amino-2′-deoxy-α-d-galactopyranosyl)-sn-glycerol, displays greater in vitro activity than edelfosine, the AEL “gold standard”. The unique properties of GAELs as antitumor agents include their apoptotic-independent mechanism of inducing cell death and the ability to kill cancer stem cells. These characteristics of GAELs offer the potential for their development into chemotherapeutic agents to prevent the recurrence of tumors as well as for treatment against drug-resistant cancers." @default.
- W2347177733 created "2016-06-24" @default.
- W2347177733 creator A5036593537 @default.
- W2347177733 creator A5048485968 @default.
- W2347177733 creator A5063258446 @default.
- W2347177733 date "2015-04-10" @default.
- W2347177733 modified "2023-09-27" @default.
- W2347177733 title "Synthetic Glycosylated Ether Glycerolipids as Anticancer Agents" @default.
- W2347177733 cites W11768824 @default.
- W2347177733 cites W1480125350 @default.
- W2347177733 cites W1490688374 @default.
- W2347177733 cites W1792499455 @default.
- W2347177733 cites W1918474545 @default.
- W2347177733 cites W1964637109 @default.
- W2347177733 cites W1967008683 @default.
- W2347177733 cites W1974702608 @default.
- W2347177733 cites W1980714336 @default.
- W2347177733 cites W1985505903 @default.
- W2347177733 cites W1988304480 @default.
- W2347177733 cites W1989855861 @default.
- W2347177733 cites W1990264243 @default.
- W2347177733 cites W2000835545 @default.
- W2347177733 cites W2001182685 @default.
- W2347177733 cites W2004538436 @default.
- W2347177733 cites W2011360946 @default.
- W2347177733 cites W2012306261 @default.
- W2347177733 cites W2016825230 @default.
- W2347177733 cites W2017325964 @default.
- W2347177733 cites W2019264784 @default.
- W2347177733 cites W2022771837 @default.
- W2347177733 cites W2023427658 @default.
- W2347177733 cites W2026379260 @default.
- W2347177733 cites W2033210402 @default.
- W2347177733 cites W2033346155 @default.
- W2347177733 cites W2036822760 @default.
- W2347177733 cites W2042936254 @default.
- W2347177733 cites W2046404871 @default.
- W2347177733 cites W2049547668 @default.
- W2347177733 cites W2051055358 @default.
- W2347177733 cites W2055088010 @default.
- W2347177733 cites W2057682849 @default.
- W2347177733 cites W2060422769 @default.
- W2347177733 cites W2062980013 @default.
- W2347177733 cites W2064640867 @default.
- W2347177733 cites W2065512205 @default.
- W2347177733 cites W2074173984 @default.
- W2347177733 cites W2076361273 @default.
- W2347177733 cites W2081568976 @default.
- W2347177733 cites W2084177956 @default.
- W2347177733 cites W2085110810 @default.
- W2347177733 cites W2091098509 @default.
- W2347177733 cites W2107845484 @default.
- W2347177733 cites W2108131089 @default.
- W2347177733 cites W2111030305 @default.
- W2347177733 cites W2124185479 @default.
- W2347177733 cites W2125365512 @default.
- W2347177733 cites W2127107445 @default.
- W2347177733 cites W2131170195 @default.
- W2347177733 cites W2133575920 @default.
- W2347177733 cites W2136846516 @default.
- W2347177733 cites W2153382986 @default.
- W2347177733 cites W2161050915 @default.
- W2347177733 cites W2161234475 @default.
- W2347177733 cites W2161748898 @default.
- W2347177733 cites W2319619421 @default.
- W2347177733 cites W2413965305 @default.
- W2347177733 cites W2428423250 @default.
- W2347177733 cites W2952840360 @default.
- W2347177733 cites W2952866872 @default.
- W2347177733 cites W8927526 @default.
- W2347177733 cites W2029971847 @default.
- W2347177733 doi "https://doi.org/10.1039/9781849739993-00151" @default.
- W2347177733 hasPublicationYear "2015" @default.
- W2347177733 type Work @default.
- W2347177733 sameAs 2347177733 @default.
- W2347177733 citedByCount "2" @default.
- W2347177733 countsByYear W23471777332017 @default.
- W2347177733 crossrefType "book-chapter" @default.
- W2347177733 hasAuthorship W2347177733A5036593537 @default.
- W2347177733 hasAuthorship W2347177733A5048485968 @default.
- W2347177733 hasAuthorship W2347177733A5063258446 @default.
- W2347177733 hasConcept C109316439 @default.
- W2347177733 hasConcept C121608353 @default.
- W2347177733 hasConcept C150487720 @default.
- W2347177733 hasConcept C178790620 @default.
- W2347177733 hasConcept C181199279 @default.
- W2347177733 hasConcept C185592680 @default.
- W2347177733 hasConcept C190283241 @default.
- W2347177733 hasConcept C202751555 @default.
- W2347177733 hasConcept C2776568683 @default.
- W2347177733 hasConcept C2780407432 @default.
- W2347177733 hasConcept C31573885 @default.
- W2347177733 hasConcept C54355233 @default.
- W2347177733 hasConcept C55493867 @default.
- W2347177733 hasConcept C71240020 @default.
- W2347177733 hasConcept C86803240 @default.
- W2347177733 hasConcept C96232424 @default.
- W2347177733 hasConceptScore W2347177733C109316439 @default.