Matches in SemOpenAlex for { <https://semopenalex.org/work/W2347183439> ?p ?o ?g. }
- W2347183439 endingPage "3286" @default.
- W2347183439 startingPage "3279" @default.
- W2347183439 abstract "Griseofulvin (GSF), a poorly water-soluble antifungal drug, is a model system for studying the physical stability of amorphous pharmaceuticals. In this study, we examined the crystallization kinetics of GSF in the bulk and at the surface as a function of temperature. A sudden 10-fold rise of bulk crystal growth rate was observed near Tg, a phenomenon similar to that observed in other molecular glasses and termed glass-to-crystal (GC) growth. Also analogous to other molecular glasses, GSF grows crystals much faster at the free surface than in the bulk. What distinguishes GSF from other systems is that surface crystallization can occur well above Tg (up to Tg + 62 °C). Another peculiar feature of GSF is that during bulk crystal growth at 130–150 °C, some crystals protruded well ahead of the normal growth front at the same growth rate as surface crystals. We suspect this protruding crystal growth is a surface-facilitated process through the formation of voids and free surfaces during bulk crystal growth. These new findings are important for understanding the mechanisms and connections for the bulk and surface crystallization in amorphous pharmaceutical solids." @default.
- W2347183439 created "2016-06-24" @default.
- W2347183439 creator A5018028121 @default.
- W2347183439 creator A5018238644 @default.
- W2347183439 date "2016-05-02" @default.
- W2347183439 modified "2023-09-25" @default.
- W2347183439 title "Fast Crystal Growth of Amorphous Griseofulvin: Relations between Bulk and Surface Growth Modes" @default.
- W2347183439 cites W1590254871 @default.
- W2347183439 cites W1964223449 @default.
- W2347183439 cites W1979364518 @default.
- W2347183439 cites W1979520497 @default.
- W2347183439 cites W1980946928 @default.
- W2347183439 cites W1984668363 @default.
- W2347183439 cites W1989410330 @default.
- W2347183439 cites W1992456610 @default.
- W2347183439 cites W1993493661 @default.
- W2347183439 cites W1994190231 @default.
- W2347183439 cites W1994418682 @default.
- W2347183439 cites W1994893251 @default.
- W2347183439 cites W2002396253 @default.
- W2347183439 cites W2018743448 @default.
- W2347183439 cites W2018919811 @default.
- W2347183439 cites W2019636172 @default.
- W2347183439 cites W2021151316 @default.
- W2347183439 cites W2022950976 @default.
- W2347183439 cites W2023886989 @default.
- W2347183439 cites W2034112061 @default.
- W2347183439 cites W2034403339 @default.
- W2347183439 cites W2041055187 @default.
- W2347183439 cites W2055284317 @default.
- W2347183439 cites W2066944305 @default.
- W2347183439 cites W2073616720 @default.
- W2347183439 cites W2087444064 @default.
- W2347183439 cites W2114479908 @default.
- W2347183439 cites W2158036413 @default.
- W2347183439 cites W2236510725 @default.
- W2347183439 cites W2256066554 @default.
- W2347183439 cites W2312370753 @default.
- W2347183439 cites W2314129420 @default.
- W2347183439 cites W2315888241 @default.
- W2347183439 cites W2320501532 @default.
- W2347183439 cites W2320844372 @default.
- W2347183439 cites W2326197465 @default.
- W2347183439 cites W2326625484 @default.
- W2347183439 cites W2327723680 @default.
- W2347183439 cites W3104190564 @default.
- W2347183439 cites W4252929690 @default.
- W2347183439 doi "https://doi.org/10.1021/acs.cgd.6b00252" @default.
- W2347183439 hasPublicationYear "2016" @default.
- W2347183439 type Work @default.
- W2347183439 sameAs 2347183439 @default.
- W2347183439 citedByCount "42" @default.
- W2347183439 countsByYear W23471834392017 @default.
- W2347183439 countsByYear W23471834392018 @default.
- W2347183439 countsByYear W23471834392019 @default.
- W2347183439 countsByYear W23471834392020 @default.
- W2347183439 countsByYear W23471834392021 @default.
- W2347183439 countsByYear W23471834392022 @default.
- W2347183439 countsByYear W23471834392023 @default.
- W2347183439 crossrefType "journal-article" @default.
- W2347183439 hasAuthorship W2347183439A5018028121 @default.
- W2347183439 hasAuthorship W2347183439A5018238644 @default.
- W2347183439 hasConcept C142724271 @default.
- W2347183439 hasConcept C159467904 @default.
- W2347183439 hasConcept C178790620 @default.
- W2347183439 hasConcept C185592680 @default.
- W2347183439 hasConcept C192562407 @default.
- W2347183439 hasConcept C199360897 @default.
- W2347183439 hasConcept C203036418 @default.
- W2347183439 hasConcept C2524010 @default.
- W2347183439 hasConcept C26456737 @default.
- W2347183439 hasConcept C2778312390 @default.
- W2347183439 hasConcept C2779819575 @default.
- W2347183439 hasConcept C2781285689 @default.
- W2347183439 hasConcept C33923547 @default.
- W2347183439 hasConcept C41008148 @default.
- W2347183439 hasConcept C56052488 @default.
- W2347183439 hasConcept C71924100 @default.
- W2347183439 hasConcept C8010536 @default.
- W2347183439 hasConceptScore W2347183439C142724271 @default.
- W2347183439 hasConceptScore W2347183439C159467904 @default.
- W2347183439 hasConceptScore W2347183439C178790620 @default.
- W2347183439 hasConceptScore W2347183439C185592680 @default.
- W2347183439 hasConceptScore W2347183439C192562407 @default.
- W2347183439 hasConceptScore W2347183439C199360897 @default.
- W2347183439 hasConceptScore W2347183439C203036418 @default.
- W2347183439 hasConceptScore W2347183439C2524010 @default.
- W2347183439 hasConceptScore W2347183439C26456737 @default.
- W2347183439 hasConceptScore W2347183439C2778312390 @default.
- W2347183439 hasConceptScore W2347183439C2779819575 @default.
- W2347183439 hasConceptScore W2347183439C2781285689 @default.
- W2347183439 hasConceptScore W2347183439C33923547 @default.
- W2347183439 hasConceptScore W2347183439C41008148 @default.
- W2347183439 hasConceptScore W2347183439C56052488 @default.
- W2347183439 hasConceptScore W2347183439C71924100 @default.
- W2347183439 hasConceptScore W2347183439C8010536 @default.
- W2347183439 hasFunder F4320321001 @default.
- W2347183439 hasIssue "6" @default.