Matches in SemOpenAlex for { <https://semopenalex.org/work/W2347210947> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2347210947 abstract "Objective To explore the mechanism that renin-angiotensin system(RAS) leads to early atherogenesis through observing the effects of ramipril on early atherogenesis in cholesterol-fed male rats.Methods Thirty male SD rats were divided into three groups:control group,hyperlipid group,and ramipril group.The rats were raised for ten weeks.Serum cholesterin,nitrous oxide(NO) and melondaldehyde(MDA) concentrations and superoxide dismutase(SOD) activity were measured.The aortas were collected for histopathlogical and immunohistochemical studies.Results Serum NO concentration and SOD activity increased significantly and serum MDA level decreased in rampril group compared with those in hyperlipide group(P0.01).NFκB activation and ICAM-1 expression level,the number of the PCNA-positive cells and the monocytes infilitrating into the intima of the aortas in hyperlipide group was significantly higher than those in Ramipril groups(P0.01).Serum cholesterin concentration of the above two groups showed no difference,but was significantly higher than that of control group.The endothelial damage of the aortas in Ramilpril groups was less severe than that in hyperlipide group.Conclusion Ramipril can prevent early atherogenesis through alleviating the damage to the arterial wall by free radicals,inhibiting the ICAM-1 expression and the monocytes infilitrating into the arterial wall." @default.
- W2347210947 created "2016-06-24" @default.
- W2347210947 creator A5042859180 @default.
- W2347210947 date "2005-01-01" @default.
- W2347210947 modified "2023-09-26" @default.
- W2347210947 title "Inhibitory effect of ramipril on early atherogenesis in male rats with diet-induced hypercholesterolemia" @default.
- W2347210947 hasPublicationYear "2005" @default.
- W2347210947 type Work @default.
- W2347210947 sameAs 2347210947 @default.
- W2347210947 citedByCount "0" @default.
- W2347210947 crossrefType "journal-article" @default.
- W2347210947 hasAuthorship W2347210947A5042859180 @default.
- W2347210947 hasConcept C126322002 @default.
- W2347210947 hasConcept C134018914 @default.
- W2347210947 hasConcept C204232928 @default.
- W2347210947 hasConcept C2775838275 @default.
- W2347210947 hasConcept C2776151105 @default.
- W2347210947 hasConcept C2778163477 @default.
- W2347210947 hasConcept C2778248901 @default.
- W2347210947 hasConcept C2779888176 @default.
- W2347210947 hasConcept C71924100 @default.
- W2347210947 hasConcept C84393581 @default.
- W2347210947 hasConceptScore W2347210947C126322002 @default.
- W2347210947 hasConceptScore W2347210947C134018914 @default.
- W2347210947 hasConceptScore W2347210947C204232928 @default.
- W2347210947 hasConceptScore W2347210947C2775838275 @default.
- W2347210947 hasConceptScore W2347210947C2776151105 @default.
- W2347210947 hasConceptScore W2347210947C2778163477 @default.
- W2347210947 hasConceptScore W2347210947C2778248901 @default.
- W2347210947 hasConceptScore W2347210947C2779888176 @default.
- W2347210947 hasConceptScore W2347210947C71924100 @default.
- W2347210947 hasConceptScore W2347210947C84393581 @default.
- W2347210947 hasLocation W23472109471 @default.
- W2347210947 hasOpenAccess W2347210947 @default.
- W2347210947 hasPrimaryLocation W23472109471 @default.
- W2347210947 hasRelatedWork W2133863398 @default.
- W2347210947 hasRelatedWork W2357547075 @default.
- W2347210947 hasRelatedWork W2361769820 @default.
- W2347210947 hasRelatedWork W2367012485 @default.
- W2347210947 hasRelatedWork W2367207599 @default.
- W2347210947 hasRelatedWork W2369958844 @default.
- W2347210947 hasRelatedWork W2370680267 @default.
- W2347210947 hasRelatedWork W2373426816 @default.
- W2347210947 hasRelatedWork W2374649603 @default.
- W2347210947 hasRelatedWork W2375375504 @default.
- W2347210947 hasRelatedWork W2379782635 @default.
- W2347210947 hasRelatedWork W2381346498 @default.
- W2347210947 hasRelatedWork W2389641927 @default.
- W2347210947 hasRelatedWork W2393267206 @default.
- W2347210947 hasRelatedWork W2404359853 @default.
- W2347210947 hasRelatedWork W2572075414 @default.
- W2347210947 hasRelatedWork W2803073259 @default.
- W2347210947 hasRelatedWork W2906080637 @default.
- W2347210947 hasRelatedWork W3001154932 @default.
- W2347210947 hasRelatedWork W3032133376 @default.
- W2347210947 isParatext "false" @default.
- W2347210947 isRetracted "false" @default.
- W2347210947 magId "2347210947" @default.
- W2347210947 workType "article" @default.