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- W2347225736 abstract "Objective:To study the relationship between the time-related changes in the 1H NMR spectral profile and the changes in blood biochemistry and histopathology,so to evaluate the feasibility to monitor the toxicity development using metabonomic techniques.Methods: In Wistar rats, the anti-tumor agent Z24(130 mg·kg-1) were orally administered for 5 days.For metabonomic analysis,the 24-h urine samples were collected before,during and after dosing until to 240 h after withdrawal.At 24 h and 240 h after withdrawal,half of rats were killed,respectively,for blood biochemical analysis and liver histopathological examination.Results: There was dependability relationship between the time-related changes in metabolic trajectory and the changes in blood biochemical analysis and liver histopathological examination.Conclusion: The phases of toxicity generation,development and recovery can be described by the metabonomic technique." @default.
- W2347225736 created "2016-06-24" @default.
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- W2347225736 date "2008-01-01" @default.
- W2347225736 modified "2023-09-27" @default.
- W2347225736 title "Metabolic trajectory analysis of urine from Wistar rats orally administrated for 5 days with Z24,a novel anti-tumor agent" @default.
- W2347225736 hasPublicationYear "2008" @default.
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