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- W2347241423 abstract "Objective To investigate the changes of microRNA-1(miRNA-1) and Kir2.1 in the left ventricular hypertrophic tissue of spontaneously hypertensive rats(SHR,and the correlation between miRNA-1 and Kir2.1).Methods Seventeen-week-old male SHRs with left ventricle hypertrophy(LVH)(n=10),8-week-old male SHRs without LVH(SHR control group n=10) and 17-week-old male Wistar-Kyoto(WKY,n=10) rats were used in this study.The pathological changes,the expression of miRNA-1 and the protein level of Kir2.1 in the left ventricular tissue were measured by HE staining,transverse diameter of myocardium,quantitative Real-Time PCR(qRT-PCR),immunohistochemical method and western blotting respectively.Results ①Compared with the WKY control group,systolic blood pressure and diastolic blood pressure were higher in LVH group and SHR control group(P0.01,P0.05 respectively).②Compared with that of the WKY and SHR control groups,the myocardial hypertrophy was more serious in LVH group with increased myocardial interstitial component,left ventricular mass index and transverse diameter of cardiomyocytes,accompanied by significantly increased level of miRNA-1 and decreased protein level of Kir2.1.③miRNA-1 expression was negatively correlated with Kir2.1 protein in LVH(r=-0.720,P0.05).Conclusion The level of miRNA-1 increases obviously in the left ventricular hypertrophic tissue of SHR rats while the protein level of Kir2.1 decreases remarkably." @default.
- W2347241423 created "2016-06-24" @default.
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- W2347241423 date "2010-01-01" @default.
- W2347241423 modified "2023-09-23" @default.
- W2347241423 title "The Expression of MicroRNA-1 and Kir2.1 in the Left Ventricular Hypertrophic Tissue of Spontaneously Hypertensive Rats" @default.
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