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- W2347310390 abstract "Natural resistance associated macrophage protein(Nramp) family is a novel family of functional related proteins with innate resistance to intracellular parasites in mammals,which has the capacity of enhancing macro-phages that are meant to kill pathogens.However,few reports are available about the structure and function of Nramp in lower vertebrates such as teleosts.In this study,cDNA of Nramp gene was amplified from liver of grass carp(Ctenopharyngodon idella) by reverse transcription polymerase chain reaction(RT-PCR) and rapid amplifi-cation of cDNA ends(RACE).The full-length cDNA of Nramp gene was 3 158 bp,including a 155 bp 5′ terminal UTR,a 1 368 bp 3′ terminal UTR and a 1 635 bp open reading frame encoding a protein with 554 amino acid residues,which contained the signature features of the Nramp protein family: 12 transmembrane(TM) domains,a consensus transport motif(CTM) with 20 amino acid residues between the transmembrane domains 8 and 9.The deduced amino acid sequence of grass carp Nramp exhibited about 62.5% 90.2% homology with 16 other verte-brate Nramp sequences.Compared with the other fish's Nramps,the unique feature of grass carp Nramp was the presence of two iron-responsive regulatory-protein-binding sites(IRE) in 3 UTR and 5 UTR.Phylogenetic analy-sis revealed that the grass carp Nramp was clustered with other fish Nramps and was closer to Nramp2 of mam-mals.RT-PCR results of grass carp Nramp transcripts in different tissues indicated that the grass carp Nramp transcripts were highly abundant in head kidney and spleen and low in muscle and skin.The grass carp kidney cells(CIK) challenged with the grass carp reovirus(GCRV) could evidently elevate Nramp mRNA levels in cell cultures." @default.
- W2347310390 created "2016-06-24" @default.
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- W2347310390 date "2011-01-01" @default.
- W2347310390 modified "2023-09-24" @default.
- W2347310390 title "Molecular cloning,characterization and expression of natural resistance associated macrophage protein(Nramp) gene cDNA from grass carp(Ctenopharyngodon idella)" @default.
- W2347310390 hasPublicationYear "2011" @default.
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