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- W2347337546 abstract "Objective To investigate the antiasthmatic effect of Xiao'er Xiaochuanning and to provide the experimental evidence for its clinical application.Methods The acetylcholine and histamine-induced asthma model in guinea pigs,lipoplysaccharides(LPS)-induced acute lung injury model in mice,ovalbumin(OVA)-induced guinea pig allergic asthma model,and OVA + LPS-induced mice allergic asthma model were used to evaluate the antiasthmatic effect of Xiao'er Xiaochuanning.Results Xiao'er Xiaochuanning(20,10,and 5 g/kg) prolonged the latent period in acetylcholine-and histamine-induced asthma of guinea pigs and OVA-induced allergic asthma of guinea pig,and could reduce the number of tumbling animals.Xiao'er Xiaochuanning(20 g/kg) could reduce the acute lung injury induced by LPS;However,the protective effect against OVA-induced eosinophilic(EOS) inflammation in guinea pigs was better than that of OVA + LPS-induced noneosinophilic(NEU) inflammation in mice.Conclusion The protection of Xiao'er Xiaochuanning against asthma is related to inhibiting the pulmonary edema and decreasing the eosinophilic infiltration in airway." @default.
- W2347337546 created "2016-06-24" @default.
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- W2347337546 date "2013-01-01" @default.
- W2347337546 modified "2023-09-26" @default.
- W2347337546 title "Research on antiasthmatic effect of Xiao'er Xiaochuanning" @default.
- W2347337546 hasPublicationYear "2013" @default.
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