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- W2347340719 abstract "AIM:The protective effect and mechanism of endogenous nitric oxide on ethanol-induced gastric mucosal damage was investigated in rats. METHODS:Macro and microscopic gastric mucosal damage and gastric mucosal blood flow and mucus secretion were assessed by pretreatment with a specific NO synthase inhibitor, N omega-nitro-L-arginine (L-NNA) or L-arginine after intragastric administration of ethanol. RESULTS:Pretreatment with L-arginine decreased significantly macro and microscopic damage caused by 50% ethanol, and L-NNA significantly increased macro and microscopic mucosal damage. Pretreatment with L-arginine increased serum nitric oxide, gastric mucosal blood flow and mucus secretion, and pretreatment with L-NNA decreased serum nitric oxide, gastric mucosal blood flow and mucus output.CONCLUSIONS:Endogenous NO modulates ethanol-induced gastric mucosal injury through regulation of gastric mucosal microcirculation and mucus secretion." @default.
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- W2347340719 date "1999-01-01" @default.
- W2347340719 modified "2023-09-24" @default.
- W2347340719 title "Protective effect of endogenous nitric oxide on ethanol-induced gastric mucosal injury in rats" @default.
- W2347340719 hasPublicationYear "1999" @default.
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