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- W2347378254 abstract "Objective To investigate the dynamic changes in endothelial cell specific molecule-1(ESM-1) in rat with sepsis and the relationship between ESM-1 level and renal injury.Methods Thirty-six SD rats were randomly divided into six groups: normal control group(n=6),sham operation group(n=6);CLP group(n=24),and in the latter group rats were divided into four subgroups according to time after CLP: CLP3h,CLP6h,CLP12h and CLP24h group(6 each).In rats of CLP group cecal ligation and puncture(CLP) was done to produce sepsis,and rats in sham operation group underwent the same surgical procedure as CLP group except the cesum was not ligated and punctured.The changes in ESM-1,blood urea nitrogen(BUN) and creatinine(Cr) level in peripheral blood were determined.Paraffin section and HE staining were used to examine pathological changes in kidney tissue,and immunohistochemisty was used to determine the ESM-1 expression in kidney tissue.Results Compared with normal control group,the serum level of ESM-1 increased significantly in CLP6h,CLP12h and CLP24h group(P0.05 or P0.01),and the serum level of BUN and Cr increased in CLP12h and CLP24h groups(P0.05).ESM-1 expression in kidney tissue showed progressive elevation as the time of CLP was prolonged(P0.01).The integrating and average optical density of ESM-1 in kidney tissue were significantly increased in CLP12h and CLP24h groups compared with those in CLP3h and CLP6h groups(P0.05).The serum ESM-1 level was positively correlated to BUN and Cr(r=0.97,P=0.01;r=0.82,P=0.04).Conclusions ESM-1 levels of serum and kidney tissue increase significantly in septic rats,which is closely related to the renal injury,and the detection is more sensitive than the routine clinical parameters of renal function in reflecting the renal pathological process." @default.
- W2347378254 created "2016-06-24" @default.
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- W2347378254 date "2009-01-01" @default.
- W2347378254 modified "2023-09-26" @default.
- W2347378254 title "Relationship between changes in endothelial cell specific molecule-1 and renal injury in sepsis rat" @default.
- W2347378254 hasPublicationYear "2009" @default.
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