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- W2347502623 abstract "Objective:To investigate changes in endogenous surfactant system after inhalation of nitric oxide (NO) in septic acute lung injury (ALI).Methods:A lipopolysaccharide induced ALI model was replicated in rabbits and NO inhalation was given.Using this model,total phosphrous (TPL),disaturated phosphatidylcholine (DSPC),small aggregates and large aggregates ratio (SA/LA),minimum surfactant films tention (γmin) of bronchioalveolar fluid(BALF) were studied.The surfactant associated protein (SPA) and SPA mRNA were measured with Western dot blot or Northern blot.Results:The results demonstrated that inhaled NO significantly improve pulmonary oxygation compared with untreated group ( P 0 01).No difference in TPL,DSPC, γmin 60,SPA protein and mRNA could be found between groups.The ratio of SA/LA (value 0 9±0 2) decreased and no further deterioration was found after inhaling NO.Conclusions:We conclude that inhalation of NO at low concentration for a short time is an effective and safe therapy." @default.
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- W2347502623 date "2000-01-01" @default.
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- W2347502623 title "Influence of inhaled nitric oxide on pulmonary surfactant in septic acute lung injury" @default.
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