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- W2347505248 abstract "Purpose Establish SD rat hypoprolactinemic abortion model induced by bromocriptine and evaluation the effect of Chinese Herbs. Methods Pregnant SD rat were divided into seven groups,each group contained 12 rats,and the model that had 6 groups was established by using bromocriptine 0.3 mg/(kg·d),sc,during pregnant day 6-8.Three groups used extract of Chinese Herbs 36 g/(kg·d) ig(A group),18 g/(kg·d)ig(B group) and powder of Chinese Herbs 3 g/(kg·d)(C group) respectively during the pregnant day 1-11,two groups used progesterone 8 mg/(kg·d) im(D group)and PRL 8 IU,bid sc(E group) respectively during the pregnant day 1-11;one group was the model group (F group).The control group was given water 3 mL,ig respectively during the pregnant day 1-11 and 75% alcohol 0.25 mL/d,sc respectively during the pregnant day 6-8 (G group).All rats were killed in pregnant day 12. Results (1) The pregnant rate,the average uterine weight and the pregnant fetus numbers of F group were significantly lower than those of B ( P 0.05),C,D,E,G( P 0.01) group.(2) The above data of A group were significantly lower than those of C,D,E,G group ( P 0.05),but no significant difference from those of B and F group ( P 0.05).(3) There were no significant difference among B,C,D,E G groups. Conclusions This animal model is beneficial for study on tocolyis effect of Chinese Herbs and spontaneous abortion pathogenesis,different dosage and manufacture had different effect." @default.
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- W2347505248 date "2002-01-01" @default.
- W2347505248 modified "2023-09-25" @default.
- W2347505248 title "Establishment of SD Rat Hypoprolactinemic Abortion Model Induced by Bromocriptine and Evaluation of the Effect of Chinese Herbs" @default.
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