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- W2347505869 abstract "Objective: To investigate the role of glycogen synthesis kinase 3β (GSK-3β) in the protection induced by EA pretreatment against cerebral ischemia/reperfusion injury.Methods: Sixty male Sprague-Dawley(SD) rats were divided into 5 groups randomly(n=12): group sham operation(Sham),group middle cerebral artery occlusion(MCAO),group electroacupuncture pretreatment(EA),group electroacupuncture pretreatment and L Y294002(EA+LY),group electroacupuncture pretreatment and vehicle(vehicle).The infarct volume and neurologic score were assessed to evaluate the ischemic injury,and GSK-3 β phosphorylation(p-GSK-3β) was detected by Western Blot.Results: Compared with group MCAO,group EA had a smaller infarct volume,and EA had a better neurologic score(P0.05).EA+LY had a larger infarct volume and worsen Garcia score compared with group vehicle(P0.05).In comparison with MCAO,EA had a higher level of p-GSK-3β than MCAO at 2 hours after reperfusion(P0.05).EA+LY had a lower p-GSK-3β level than EA(P0.05).Conclusion: EA pretreatment may protect brain from ischemia/reperfusion injury by promoting phosphorylation of GSK-3β in rats." @default.
- W2347505869 created "2016-06-24" @default.
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- W2347505869 date "2013-01-01" @default.
- W2347505869 modified "2023-09-26" @default.
- W2347505869 title "Electroacupuncture Pretreatment Induces Cerebral Ischemic Tolerance by Enhancing Phosphorylation of Glycogen Synthesis Kinase 3β in Rats" @default.
- W2347505869 hasPublicationYear "2013" @default.
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