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- W2347506118 abstract "[Objective] To study the effect of targeted magnetic nanoparticles containing 5-Fu on expression of bcl-2/bax protein in transplanted liver cancer in nude mice.[Methods] Morphological characteristics of transplanted tumors were studied by electron microscope.The expression of bcl-2/bax protein was detected by immunohistochemistry(SABC).[Results] The phenomenon of apoptosis was observed in group B(5-Fu)and group D(magnetic nanoparticles containing 5-Fu and magnetic field built inside tumor tissue)by electron microscope.The expression of bcl-2 was markedly decreased but that of bax markedly increased in group B and group D than in group A(NS),group C(magnetic nanoparticles containing 5-Fu)and group E(magnetic nanoparticles without 5-Fu and magnetic field built inside tumor tissue)(P 0.01).The expression of bcl-2 was markedly decreased but that of bax markedly increased in group D than in group B(P0.01).[Conclusion] The targeted therapy of magnetic nanoparticles containing 5-Fu can inhibit the growth of hepatocellular carcinoma and up-regulate apoptosis of the liver cancer cells by decrease the expression of bcl-2 gene,increase the expression of bax gene." @default.
- W2347506118 created "2016-06-24" @default.
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- W2347506118 date "2006-01-01" @default.
- W2347506118 modified "2023-09-26" @default.
- W2347506118 title "Effect of targeted magnetic nanoparticles containing 5-Fu on expression of bcl-2/bax protein in transplanted liver cancer in nude mice" @default.
- W2347506118 hasPublicationYear "2006" @default.
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