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- W2347511418 abstract "Objective To establish an animal model of rheumatoid arthritis(RA) and isolate fibroblast-like synoviocytes(FLS) from inflammatory synovium.Methods Modified adjuvant was prepared using heat-killed Mycobacterium tuberculosis H37Ra with sterile mineral oil,and arthritis was induced in Lewis rats by injection of the adjuvant at base of tail.Synovial tissue specimens were taken from arthritic ankle joints followed by mincing adequately.FLS were isolated by collagenase digestion.Results Arthritis was successfully induced in the rats.The incidence reached 100% with regular time of arthritis development,and the histological changls were similar to those of rheumatoid arthritis.FLS were successfully obtained,identified and characterized in vitro.Conclusions An animal model of RA has been successfully established in rats and FLS have been successfully obtained,providing a desirable in vivo animal model and in vitro cell model for exploration of RA pathogenesis and drug evaluation." @default.
- W2347511418 created "2016-06-24" @default.
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- W2347511418 date "2012-01-01" @default.
- W2347511418 modified "2023-09-25" @default.
- W2347511418 title "Establishment of a rat model of adjuvant-induced arthritis and isolation of fibroblast-like synoviocytes" @default.
- W2347511418 hasPublicationYear "2012" @default.
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