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- W2347521802 abstract "OBJECTIVE:To examine the expression of glucocorticoid receptor in human colon carcinoma samples and cell lines,explore the effects of GR on the colon cancer cells in vitro,and attempt to define the functional role of GRβ during the steroid response.METHODS:The GR expression was investigated in colon carcinoma tissue samples and cell lines by using immunohistochemical assays.The effects of dexamethasone(Dex)on colon cancer cells were detected by MTT and annexinⅤ-FITC/PI FCM.The regulation of GRα and GRβ by Dex was analyzed by RT-PCR.The effects of silencing GRβ mRNA on Dex-induced apoptosis were assessed.RESULTS:GR was expressed in 57.3% of colon carcinoma and in LoVo and HCT116,not in HT29 and SW480.Dex inhibited cell growth and induced apoptosis in the GR-positive LoVo and HCT116 cells.The expressions of both GRα and GRβ mRNA increased than their basal expression levels with Dex treatment,and the expression of GRβ increased more significantly.The mRNA expression of GRβ decreased by 67.3% in LoVo cells with liposome-mediated transfection of synthesized GRβ siRNA and its rate of Dex-induced apoptosis increased from(34.7±1.8)% to(45.4±4.3)%(P0.05).CONCLUSION:The inhibitions of proliferation and apoptosis do occur on the GR-positive colon carcinoma cells induced by Dex in vitro,and elevated GRβ may inhibit cells' response to steroids." @default.
- W2347521802 created "2016-06-24" @default.
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- W2347521802 date "2010-01-01" @default.
- W2347521802 modified "2023-09-28" @default.
- W2347521802 title "Relationship of glucocorticoid receptor β expression with sensitivity of colon carcinoma cells" @default.
- W2347521802 hasPublicationYear "2010" @default.
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