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- W2347547829 abstract "Objective To explore the influence of patients who accepted chemotherapy of Folfox4 scheme before operation for the expression of miR-196 and HoxB8 in colorectal cancer, and illustrating the differences between the miR-196 and HoxB8 expressions in colorectal cancer tissues and sensitivity to chemotherapy with Folfox4 scheme and its correlation and significance. Methods Fluorescence quantitative PCR( RT-PCR)and immunohistochemistry were used to determine the expressions of miR-196 and HoxB8 in 50 specimens of neoadjuvant chemotherapy group( chemotherapy sensitive group and chemotherapy insensitive group) and 30 specimens which received the surgery directly( no-chemotherapy group), and analyzing the relationship and discrepancy between miR-196 and HoxB8 in these groups. Results The RT-PCR examination showed that the relative expression levels of miR-196 and HoxB8 in the neoadjuvant chemotherapy group were lower than the no-chemotherapy group( 0.646 8±0.683 9 vs. 1.000 0±0.000 0, P0.01;0.607 6±0.418 9 vs. 1.000 0±0.000 0, P0.01). Expression of miR-196 in the chemotherapy sensitive group was higher than the chemotherapy insensitive group( 0.948 9±0.691 0 vs. 0.344 7±0.536 1, P0.01), however, the expression of HoxB8 mRNA in the chemotherapy sensitive group was lower than the chemotherapy insensitive group( 0.489 9±0.371 5 vs. 0.725 3±0.437 5, P 0.05). Expression positive rate of HoxB8 protein in chemotherapy sensitive group was lower than the chemotherapy insensitive group(Z=-2.396,P=0.017). The expressions of miR-196 and HoxB8 in the neoadjuvant chemotherapy group had negative relationship(r=-0.595, P0.01), which was also exist in the no-chemotherapy group(r=-0.435, P0.01). Conclusions The neoadjuvant chemotherapy with Folfox4 scheme before operation can reduce the expression levels of miR-196 and HoxB8 in colorectal cancer tisssues. The different expression levels of miR-196 and HoxB8 could influence the sensitivity of neoadjuvant chemotherapy with Folfox4 scheme in colorectal cancer. The high level expression of miR-196 could restrain the expression of HoxB8, and then increase the sensitivity of chemotherapy with Folfox4 scheme in colorectal cancer." @default.
- W2347547829 created "2016-06-24" @default.
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- W2347547829 date "2014-01-01" @default.
- W2347547829 modified "2023-09-26" @default.
- W2347547829 title "MiR-196 and HoxB8 Influence on The Sensitivity of Neoadjuvant Chemotherapy with Folfox4 Scheme in Colorectal Cancer" @default.
- W2347547829 hasPublicationYear "2014" @default.
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