Matches in SemOpenAlex for { <https://semopenalex.org/work/W2347558957> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2347558957 abstract "Objective To study the protective effect of NF-κB decoy oligodeoxynucleotides(ODNs) on endotoxin-induced liver injury in the rat and its mechanism.Methods Sixty Sprague-Dawley rats were randomly divided into control group,endotoxin(LPS) group and NF-κB decoy ODNs group.Liver and serum samples were collected 24 h after operation.The NF-κB binding activity was detected with electrophoretic mobility shift assay(EMSA),histopathologic change of liver was examined by light microscope,and cell apoptosis was detected by TUNEL.Liver enzyme(AST),TNF-α and IL-6 in serum were also detected.Results Compared to control group,in LPS group,NF-κB was dramatically increased induced apoptosis of large numbers of hepatocytes,and severe liver damage,the expression of AST,TNF-α and IL-6 were also significantly increased(P0.01).However,compared with control group in NF-κB decoy ODNs group,the activation of TNF-κB depressed,the hepatic histopathologic changes and apoptosis of hepatocytes were also relieved,and expression of TNF-α and AST levels decreased(P0.01).On the other hand,the expression of IL-6 was not significantly decreased by NF-κB decoy compared with LPS group(P0.05).Conclusions NF-κB decoy strategy can efficiently inhibit the binding activity of NF-κB,and thus suppress the production of downstream cytokines,which may play a crucial role in protecting the liver from endotoxin-induced injury." @default.
- W2347558957 created "2016-06-24" @default.
- W2347558957 creator A5025819567 @default.
- W2347558957 date "2010-01-01" @default.
- W2347558957 modified "2023-09-26" @default.
- W2347558957 title "The protective effect of nuclear factor-κB decoy oligodeoxynucleotides on entotoxin-induced liver injury and its mechanism" @default.
- W2347558957 hasPublicationYear "2010" @default.
- W2347558957 type Work @default.
- W2347558957 sameAs 2347558957 @default.
- W2347558957 citedByCount "0" @default.
- W2347558957 crossrefType "journal-article" @default.
- W2347558957 hasAuthorship W2347558957A5025819567 @default.
- W2347558957 hasConcept C104317684 @default.
- W2347558957 hasConcept C126322002 @default.
- W2347558957 hasConcept C134018914 @default.
- W2347558957 hasConcept C153911025 @default.
- W2347558957 hasConcept C16685009 @default.
- W2347558957 hasConcept C170493617 @default.
- W2347558957 hasConcept C17991360 @default.
- W2347558957 hasConcept C183978625 @default.
- W2347558957 hasConcept C185592680 @default.
- W2347558957 hasConcept C190283241 @default.
- W2347558957 hasConcept C196795494 @default.
- W2347558957 hasConcept C203014093 @default.
- W2347558957 hasConcept C204232928 @default.
- W2347558957 hasConcept C2776637226 @default.
- W2347558957 hasConcept C2776914184 @default.
- W2347558957 hasConcept C2777730290 @default.
- W2347558957 hasConcept C2779179475 @default.
- W2347558957 hasConcept C55493867 @default.
- W2347558957 hasConcept C71924100 @default.
- W2347558957 hasConcept C86339819 @default.
- W2347558957 hasConcept C86803240 @default.
- W2347558957 hasConceptScore W2347558957C104317684 @default.
- W2347558957 hasConceptScore W2347558957C126322002 @default.
- W2347558957 hasConceptScore W2347558957C134018914 @default.
- W2347558957 hasConceptScore W2347558957C153911025 @default.
- W2347558957 hasConceptScore W2347558957C16685009 @default.
- W2347558957 hasConceptScore W2347558957C170493617 @default.
- W2347558957 hasConceptScore W2347558957C17991360 @default.
- W2347558957 hasConceptScore W2347558957C183978625 @default.
- W2347558957 hasConceptScore W2347558957C185592680 @default.
- W2347558957 hasConceptScore W2347558957C190283241 @default.
- W2347558957 hasConceptScore W2347558957C196795494 @default.
- W2347558957 hasConceptScore W2347558957C203014093 @default.
- W2347558957 hasConceptScore W2347558957C204232928 @default.
- W2347558957 hasConceptScore W2347558957C2776637226 @default.
- W2347558957 hasConceptScore W2347558957C2776914184 @default.
- W2347558957 hasConceptScore W2347558957C2777730290 @default.
- W2347558957 hasConceptScore W2347558957C2779179475 @default.
- W2347558957 hasConceptScore W2347558957C55493867 @default.
- W2347558957 hasConceptScore W2347558957C71924100 @default.
- W2347558957 hasConceptScore W2347558957C86339819 @default.
- W2347558957 hasConceptScore W2347558957C86803240 @default.
- W2347558957 hasLocation W23475589571 @default.
- W2347558957 hasOpenAccess W2347558957 @default.
- W2347558957 hasPrimaryLocation W23475589571 @default.
- W2347558957 hasRelatedWork W1992961242 @default.
- W2347558957 hasRelatedWork W2307435968 @default.
- W2347558957 hasRelatedWork W2359528579 @default.
- W2347558957 hasRelatedWork W2363652269 @default.
- W2347558957 hasRelatedWork W2394870648 @default.
- W2347558957 hasRelatedWork W2914321392 @default.
- W2347558957 hasRelatedWork W2988234451 @default.
- W2347558957 hasRelatedWork W2990433537 @default.
- W2347558957 hasRelatedWork W2994200097 @default.
- W2347558957 hasRelatedWork W2997245282 @default.
- W2347558957 hasRelatedWork W3011877091 @default.
- W2347558957 hasRelatedWork W3025142517 @default.
- W2347558957 hasRelatedWork W3025729528 @default.
- W2347558957 hasRelatedWork W3026291831 @default.
- W2347558957 hasRelatedWork W3029736620 @default.
- W2347558957 hasRelatedWork W3029935648 @default.
- W2347558957 hasRelatedWork W3030529409 @default.
- W2347558957 hasRelatedWork W3101259024 @default.
- W2347558957 hasRelatedWork W3119775430 @default.
- W2347558957 hasRelatedWork W3134637650 @default.
- W2347558957 isParatext "false" @default.
- W2347558957 isRetracted "false" @default.
- W2347558957 magId "2347558957" @default.
- W2347558957 workType "article" @default.