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- W2347564447 abstract "Objective To discuss the interaction of aripiprazole combined with clozapine in treatment of schizophrenia,in order to make suitable dose of this combination therapy explicit.Methods A total of 97 cases of schizophrenia diagnosed in our hospital between Oct.,2011 and May,2013 were divided into 4groups(low dose of aripiprazole combined with low dose of clozapine,low dose of aripiprazole combined with high dose of clozapine,high dose of aripiprazole combined with low dose of clozapine,high dose of aripiprazole combined with high dose of clozapine).The results of efficacy and side effects were all recorded and analyzed.Results In treatment efficacy,high dose of aripiprazole and clozapine was the best,when compared with other 3groups(P0.05),low dose of aripiprazole and clozapine was the worst(P0.05).On the other hand,the incidence of side effects was highest in group of high dose of aripiprazole and clozapine,group of high dose of aripiprazole combined with low dose of clozapine and group of low dose of aripiprazole and clozapine were better than others in safety.Conclusion The efficacy and side effects of aripiprazole and clozapine are dose dependent,when using these two medicines to treat schizophrenia,the doses should be suitable to make good efficacy and avoid side effects.If the side effects are obvious,the dose of clozapine should be decreased,however,the dose of aripiprazole can be decreased extenuatorily;If the patients can tolerate the treatment,the doses of these two medicine can be increased." @default.
- W2347564447 created "2016-06-24" @default.
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- W2347564447 date "2014-01-01" @default.
- W2347564447 modified "2023-09-23" @default.
- W2347564447 title "Interaction of aripiprazole combined with clozapine in treatment of schizophrenia" @default.
- W2347564447 hasPublicationYear "2014" @default.
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